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dc.contributor.authorMorein-Zamir, S.
dc.contributor.authorFineberg, Naomi
dc.contributor.authorRobbins, T.W.
dc.contributor.authorSahakian, B.J.
dc.date.accessioned2010-03-16T14:29:07Z
dc.date.available2010-03-16T14:29:07Z
dc.date.issued2010
dc.identifier.citationMorein-Zamir , S , Fineberg , N , Robbins , T W & Sahakian , B J 2010 , ' Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype? ' , Psychological Medicine , vol. 40 , no. 2 , pp. 263-272 . https://doi.org/10.1017/S003329170999033X
dc.identifier.issn0033-2917
dc.identifier.otherPURE: 195178
dc.identifier.otherPURE UUID: b7fe62f7-61bc-42f7-95e1-76f8ef960557
dc.identifier.otherdspace: 2299/4343
dc.identifier.otherScopus: 76649109584
dc.identifier.urihttp://hdl.handle.net/2299/4343
dc.descriptionOriginal article can be found at: http://journals.cambridge.org/ Copyright © Cambridge University Press 2009 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>.
dc.description.abstractBackground: Obsessive-compulsive disorder (OCD) has been associated with impairments in stop-signal inhibition, a measure of motor response suppression. The study used a novel paradigm to examine both thought suppression and response inhibition in OCD, where the modulatory effects of stimuli relevant to OCD could also be assessed. Additionally, the study compared inhibitory impairments in OCD patients with and without co-morbid depression, as depression is the major co-morbidity of OCD. Method: Volitional response suppression and unintentional thought suppression to emotive and neutral stimuli were examined using a novel thought stop-signal task. The thought stop-signal task was administered to non-depressed OCD patients, depressed OCD patients and healthy controls (n=20 per group). Results: Motor inhibition impairments were evident in OCD patients, while motor response performance did not differ between patients and controls. Switching to a new response but not motor inhibition was affected by stimulus relevance in OCD patients. Additionally, unintentional thought suppression as measured by repetition priming was intact. OCD patients with and without depression did not differ on any task performance measures, though there were significant differences in all self-reported measures. Conclusions: Results support motor inhibition deficits in OCD that remain stable regardless of stimulus meaning or co-morbid depression. Only switching to a new response was influenced by stimulus meaning. When response inhibition was successful in OCD patients, so was the unintentional suppression of the accompanying thought.en
dc.language.isoeng
dc.relation.ispartofPsychological Medicine
dc.rightsOpen
dc.titleInhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?en
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2010
rioxxterms.versionVoR
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1017/S003329170999033X
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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