dc.contributor.author | Learoyd, Tristan | |
dc.contributor.author | Burrows, J.L. | |
dc.contributor.author | French, E. | |
dc.contributor.author | Seville, P.C. | |
dc.date.accessioned | 2010-04-07T08:57:18Z | |
dc.date.available | 2010-04-07T08:57:18Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Learoyd , T , Burrows , J L , French , E & Seville , P C 2010 , ' Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions ' , Journal of Microencapsulation , vol. 27 , no. 2 , pp. 162-170 . https://doi.org/10.3109/02652040903052044 | |
dc.identifier.issn | 0265-2048 | |
dc.identifier.other | dspace: 2299/4375 | |
dc.identifier.uri | http://hdl.handle.net/2299/4375 | |
dc.description | Original article can be found at: http://informahealthcare.com/doi/abs/10.3109/02652040903052044 Copyright Informa Healthcare. [Full text of this article is not available in the UHRA] | |
dc.description.abstract | The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or beclometasone dipropionate in varying phases. The double emulsions contained the drug release modifier polylactide co-glycolide (PLGA 50 : 50) in the intermediate organic phase of the original micro-emulsion and low molecular weight chitosan (Mw<190 kDa: emulsion stabilizer) and leucine (aerosolization enhancer) in the tertiary aqueous phase. Following spray-drying resultant powders were physically characterized: with in vitro aerosolization performance and drug release investigated using a Multi-Stage Liquid Impinger and modified USP II dissolution apparatus, respectively. Powders generated were of a respirable size exhibiting emitted doses of over 95% and fine particle fractions of up to 60% of the total loaded dose. Sustained drug release profiles were observed during dissolution for powders containing agents in the primary aqueous and secondary organic phases of the original micro-emulsion; the burst release of agents was witnessed from the tertiary aqueous phase. The novel spray-dried emulsions from this study would be expected to deposit and display sustained release character in the lung. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Microencapsulation | |
dc.title | Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions | en |
dc.contributor.institution | Department of Pharmacy | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.3109/02652040903052044 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |