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dc.contributor.authorLearoyd, Tristan
dc.contributor.authorBurrows, J.L.
dc.contributor.authorFrench, E.
dc.contributor.authorSeville, P.C.
dc.date.accessioned2010-04-07T08:57:18Z
dc.date.available2010-04-07T08:57:18Z
dc.date.issued2010
dc.identifier.citationLearoyd , T , Burrows , J L , French , E & Seville , P C 2010 , ' Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions ' , Journal of Microencapsulation , vol. 27 , no. 2 , pp. 162-170 . https://doi.org/10.3109/02652040903052044
dc.identifier.issn0265-2048
dc.identifier.otherPURE: 183096
dc.identifier.otherPURE UUID: 13ad46ee-311e-4b44-bc75-c717bab7068b
dc.identifier.otherdspace: 2299/4375
dc.identifier.otherScopus: 77149147746
dc.identifier.urihttp://hdl.handle.net/2299/4375
dc.descriptionOriginal article can be found at: http://informahealthcare.com/doi/abs/10.3109/02652040903052044 Copyright Informa Healthcare. [Full text of this article is not available in the UHRA]
dc.description.abstractThe sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or beclometasone dipropionate in varying phases. The double emulsions contained the drug release modifier polylactide co-glycolide (PLGA 50 : 50) in the intermediate organic phase of the original micro-emulsion and low molecular weight chitosan (Mw<190 kDa: emulsion stabilizer) and leucine (aerosolization enhancer) in the tertiary aqueous phase. Following spray-drying resultant powders were physically characterized: with in vitro aerosolization performance and drug release investigated using a Multi-Stage Liquid Impinger and modified USP II dissolution apparatus, respectively. Powders generated were of a respirable size exhibiting emitted doses of over 95% and fine particle fractions of up to 60% of the total loaded dose. Sustained drug release profiles were observed during dissolution for powders containing agents in the primary aqueous and secondary organic phases of the original micro-emulsion; the burst release of agents was witnessed from the tertiary aqueous phase. The novel spray-dried emulsions from this study would be expected to deposit and display sustained release character in the lung.en
dc.language.isoeng
dc.relation.ispartofJournal of Microencapsulation
dc.titleSustained delivery of salbutamol and beclometasone from spray-dried double emulsionsen
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dcterms.dateAccepted2010
rioxxterms.versionofrecordhttps://doi.org/10.3109/02652040903052044
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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