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dc.contributor.authorO'Shaughnessy, K.M.
dc.contributor.authorFu, B.
dc.contributor.authorDickerson, Claire
dc.contributor.authorThurston, D.
dc.contributor.authorBrown, M.J.
dc.identifier.citationO'Shaughnessy , K M , Fu , B , Dickerson , C , Thurston , D & Brown , M J 2000 , ' The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects ' , Clinical Science , vol. 99 , no. 3 , pp. 233-238 .
dc.identifier.otherPURE: 106699
dc.identifier.otherPURE UUID: f8049703-f1db-4420-831e-dc840d725e33
dc.identifier.otherdspace: 2299/4500
dc.identifier.otherScopus: 0033821403
dc.descriptionOriginal article can be found at: Copyright The Biochemical Society and the Medical Research Society [Full text of this article is not available in the UHRA]
dc.description.abstractMutation scanning of the b1-adrenoceptor gene has identified a polymorphism, G389R, that markedly affects G-protein coupling of the receptor and resulting cAMP production. We have investigated the effect of this functionally active polymorphism on clinical response to b-adrenoceptor blockade. Two cohorts of untreated hypertensive patients randomly assigned to a b1-selective b-blocker at the start of antihypertensive therapy were studied retrospectively to see if the G389R polymorphism influenced the response in terms of blood pressure and heart rate. The blood pressure and heart rate responses to treatment were assessed 4 weeks later and compared with the G389R genotype, ascertained by PCR/restriction fragment length polymorphism. The falls in blood pressure and heart rate for the first group (n = 92) by genotype were: GG, 20.1±3.5/13.9±2.7 mmHg (systolic/diastolic blood pressure), 18.4±2.2 beats/min; GR, 20.0±2.2/15.0±1.3 mmHg, 16.5±1.5 beats/min; RR, 20.8±2.3/13.4±1.1 mmHg, 16.0±1.4 beats/min. For the second group (n = 55) the corresponding falls were: GG, 17.0±4.3/11.2±3.4 mmHg, 12.0±3.5 beats/min; GR, 16.6±1.8/14.4±1.1 mmHg, 13.1±2.1 beats/min; RR, 18.0±1.6/13.0±1.4 mmHg, 14.4±1.4 beats/min. The G389R genotype also failed to have a significant effect on pretreatment blood pressure or heart rate in either group. These data suggest that, despite clear functional differences between the G389R receptor variants expressed in vitro, the polymorphism does not affect the haemodynamic response of hypertensive subjects to chronic b1-adrenoceptor blockade.en
dc.relation.ispartofClinical Science
dc.titleThe gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjectsen
dc.contributor.institutionSchool of Education
dc.contributor.institutionSocial Sciences, Arts & Humanities Research Institute
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Education
rioxxterms.typeJournal Article/Review

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