Show simple item record

dc.contributor.authorJia, H.
dc.contributor.authorSharma, P.
dc.contributor.authorHopper, R.
dc.contributor.authorDickerson, Claire
dc.contributor.authorLloyd, D.D.
dc.contributor.authorBrown, M.J.
dc.identifier.citationJia , H , Sharma , P , Hopper , R , Dickerson , C , Lloyd , D D & Brown , M J 2000 , ' [beta]2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians ' , Journal of Hypertension , vol. 18 , no. 6 , pp. 687-93 .
dc.identifier.otherPURE: 105451
dc.identifier.otherPURE UUID: 12d2c966-c46d-4482-ac60-02a9f863be3b
dc.identifier.otherdspace: 2299/4501
dc.identifier.otherScopus: 0033623878
dc.descriptionOriginal article can be found at: Copyright: 2000 Lippincott Williams & Wilkins, Inc. [Full text of this article is not available in the UHRA]
dc.description.abstractObjective: The amino-terminal polymorphisms, Arg16Gly and Gln27Glu, of the [beta]2-adrenergic receptor ([beta]2AR) have been shown to affect regulation of the receptor expression by an agonist in cell culture studies. The Arg16Gly polymorphism has also been recently shown to be associated with essential hypertension. We therefore evaluated whether the amino-terminal polymorphisms of [beta]2AR are associated with hypertension in a Caucasian population. Subjects and methods: We performed an association study in 298 hypertensive patients and an equal number of age-matched normotensive controls from the East Anglian region, with blood pressure assessed categorically and quantitatively. We also examined the influence of the amino-terminal polymorphisms on blood pressure response to [beta]-blockade in 144 of the patients randomly assigned to this class of drug. Genotyping of the Arg16Gly polymorphism was undertaken by a newly designed mismatched polymerase chain reaction (PCR) and digestion with Nde I, whereas the Gln27Glu polymorphism was genotyped by PCR followed by Fnu4H I cleavage. Results: We found no differences in the genotype or allele frequencies of the [beta]2AR polymorphisms between hypertensive and normotensive participants. There was also no association between the [beta]2AR genotypes and variations in either basal blood pressure or the blood pressure response to a [beta]-blocker. Conclusion: These findings suggest that the amino-terminal polymorphisms of the [beta]2AR gene are unlikely to constitute major susceptibility for essential hypertension in the East Anglian population.en
dc.relation.ispartofJournal of Hypertension
dc.title[beta]2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasiansen
dc.contributor.institutionSchool of Education
dc.contributor.institutionSocial Sciences, Arts & Humanities Research Institute
dc.contributor.institutionCentre for Research in Professional and Work-Related Learning
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record