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dc.contributor.authorNg, Q-S.
dc.contributor.authorGoh, V.
dc.contributor.authorMilner, J.
dc.contributor.authorSundin, J.
dc.contributor.authorWellsted, D.
dc.contributor.authorSaunders, M.I.
dc.contributor.authorHoskin, P.J.
dc.identifier.citationNg , Q-S , Goh , V , Milner , J , Sundin , J , Wellsted , D , Saunders , M I & Hoskin , P J 2010 , ' Quantitative helical dynamic contrast enhanced computed tomography assessment of the spatial variation in whole tumour blood volume with radiotherapy in lung cancer ' , Lung Cancer , vol. 69 , no. 1 , pp. 71-76 .
dc.identifier.otherPURE: 116461
dc.identifier.otherPURE UUID: 844f16e3-cad8-4191-b7a4-2835d9164f58
dc.identifier.otherdspace: 2299/4599
dc.identifier.otherScopus: 77953362378
dc.descriptionOriginal article can be found at: Copyright Elsevier Ireland Ltd. [Full text of this article is not available in the UHRA]
dc.description.abstractWe aim to assess the spatial distribution of blood volume (BV) in whole lung tumours in patients undergoing radiotherapy using helical dynamic contrast enhanced computed tomography (DCE-CT), and to determine whether conventional single level, or whole tumour measurements is more representative of the vascular effects of radiotherapy. Following ethical approval and informed consent, 15 patients with histologically proven non-small cell lung cancer underwent paired helical DCE-CT studies at baseline to assess repeatability, and after two fractions of radiotherapy (9 Gy total dose). Tumour BV was calculated for individual contiguous 10 mm axial slices, and for the entire tumour volume on a pixel-per-pixel basis. Baseline tumour BV was heterogeneous varying by 15.33% ± 17.11 between adjacent 10 mm axial slices. Within subject coefficient of variation was 36.72% with conventional single tumour level evaluation, and 13.62% with whole tumour measurements. Following radiotherapy, one patient had an increase in BV greater than baseline variation (derived from the 95% limits of change) using single level evaluation; in contrast, seven patients had an increase in BV when the whole tumour was assessed. As a group, following radiotherapy, mean BV increased by 17.27% (paired t-test, p = 0.20) with single level evaluation and 19.26% (p = 0.049) with whole tumour assessment. Tumour BV measured using DCE-CT is spatially heterogeneous. Given the slice-by-slice variation in blood volume, our results demonstrate that whole tumour DCE-CT measurements are more repeatable, and may be a better predictor of vascular changes following therapy, compared to conventional single tumour level evaluations.en
dc.relation.ispartofLung Cancer
dc.titleQuantitative helical dynamic contrast enhanced computed tomography assessment of the spatial variation in whole tumour blood volume with radiotherapy in lung canceren
dc.contributor.institutionDepartment of Allied Health Professions and Midwifery
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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