dc.contributor.author | Staff, K. | |
dc.contributor.author | Brown, Marc | |
dc.contributor.author | Hider, R. C. | |
dc.contributor.author | Kong, X. L. | |
dc.contributor.author | Friden, P. | |
dc.contributor.author | Jones, S. A. | |
dc.date.accessioned | 2010-09-20T08:58:00Z | |
dc.date.available | 2010-09-20T08:58:00Z | |
dc.date.issued | 2010-09 | |
dc.identifier.citation | Staff , K , Brown , M , Hider , R C , Kong , X L , Friden , P & Jones , S A 2010 , ' Recovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatography ' , Biomedical Chromatography , vol. 24 , no. 9 , pp. 1015-1022 . https://doi.org/10.1002/bmc.1402 | |
dc.identifier.issn | 0269-3879 | |
dc.identifier.other | dspace: 2299/4831 | |
dc.identifier.uri | http://hdl.handle.net/2299/4831 | |
dc.description | The definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright John Wiley & Sons, Ltd. [Full text of this article is not available in the UHRA] | |
dc.description.abstract | Ion exchange chelation chromatography is an effective means to extract metals from coordination complexes and biological samples; however there is a lack of data to verify the nature of metal complexes that can be successfully analysed using such a procedure. The aim of this study was to assess the capability of pyridine 2,6-dicarboxylic acid (PDCA) to extract and quantify Ga(III) from a range of environments using standard liquid chromatography apparatus. The PDCA chelation method generated a single Ga(III) peak with a retention time of 2.55 +/- 0.02 min, a precision of <2% and a limit of detection of 110 mu M. Ga(III) hydroxide complexes (highest stability constant 15.66) were used to successfully cross-validate the chelation method with inductively coupled plasma mass spectrometry. The PDCA assay extracted 96.9 +/- 1.2% of the spiked Ga(III) from porcine mucus and 100.7 +/- 2.7% from a citrate complex (stability constant 10.02), but only ca 50% from an EDTA complex (stability constant 22.01). These data suggest that PDCA chelation can be considered a suitable alternative to inductively coupled plasma mass spectrometry for Ga(III) quantification from all but the most strongly bound coordinated complexes i.e. a stability constant of >15. Copyright (C) 2010 John Wiley & Sons, Ltd. | en |
dc.format.extent | 8 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biomedical Chromatography | |
dc.subject | gallium | |
dc.subject | ion exchange | |
dc.subject | liquid chromatography | |
dc.subject | coordination | |
dc.subject | 300 DEGREES-C | |
dc.subject | GALLIUM NITRATE | |
dc.subject | METAL-IONS | |
dc.subject | TRANSITION-METALS | |
dc.subject | SEPARATION | |
dc.subject | SPECIATION | |
dc.subject | EXCHANGE | |
dc.subject | BINDING | |
dc.subject | INDIUM | |
dc.subject | SOLUBILITY | |
dc.title | Recovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatography | en |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1002/bmc.1402 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |