Show simple item record

dc.contributor.authorStaff, K.
dc.contributor.authorBrown, Marc
dc.contributor.authorHider, R. C.
dc.contributor.authorKong, X. L.
dc.contributor.authorFriden, P.
dc.contributor.authorJones, S. A.
dc.date.accessioned2010-09-20T08:58:00Z
dc.date.available2010-09-20T08:58:00Z
dc.date.issued2010-09
dc.identifier.citationStaff , K , Brown , M , Hider , R C , Kong , X L , Friden , P & Jones , S A 2010 , ' Recovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatography ' Biomedical Chromatography , vol. 24 , no. 9 , pp. 1015-1022 . https://doi.org/10.1002/bmc.1402
dc.identifier.issn0269-3879
dc.identifier.otherPURE: 184440
dc.identifier.otherPURE UUID: 0edc722e-5854-4fbf-8151-ff97eebb2204
dc.identifier.otherdspace: 2299/4831
dc.identifier.otherWOS: 000281424600015
dc.identifier.otherScopus: 77957196650
dc.identifier.urihttp://hdl.handle.net/2299/4831
dc.descriptionThe definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright John Wiley & Sons, Ltd. [Full text of this article is not available in the UHRA]
dc.description.abstractIon exchange chelation chromatography is an effective means to extract metals from coordination complexes and biological samples; however there is a lack of data to verify the nature of metal complexes that can be successfully analysed using such a procedure. The aim of this study was to assess the capability of pyridine 2,6-dicarboxylic acid (PDCA) to extract and quantify Ga(III) from a range of environments using standard liquid chromatography apparatus. The PDCA chelation method generated a single Ga(III) peak with a retention time of 2.55 +/- 0.02 min, a precision of <2% and a limit of detection of 110 mu M. Ga(III) hydroxide complexes (highest stability constant 15.66) were used to successfully cross-validate the chelation method with inductively coupled plasma mass spectrometry. The PDCA assay extracted 96.9 +/- 1.2% of the spiked Ga(III) from porcine mucus and 100.7 +/- 2.7% from a citrate complex (stability constant 10.02), but only ca 50% from an EDTA complex (stability constant 22.01). These data suggest that PDCA chelation can be considered a suitable alternative to inductively coupled plasma mass spectrometry for Ga(III) quantification from all but the most strongly bound coordinated complexes i.e. a stability constant of >15. Copyright (C) 2010 John Wiley & Sons, Ltd.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofBiomedical Chromatography
dc.subjectgallium
dc.subjection exchange
dc.subjectliquid chromatography
dc.subjectcoordination
dc.subject300 DEGREES-C
dc.subjectGALLIUM NITRATE
dc.subjectMETAL-IONS
dc.subjectTRANSITION-METALS
dc.subjectSEPARATION
dc.subjectSPECIATION
dc.subjectEXCHANGE
dc.subjectBINDING
dc.subjectINDIUM
dc.subjectSOLUBILITY
dc.titleRecovering Ga(III) from coordination complexes using pyridine 2,6-dicarboxylic acid chelation ion chromatographyen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1002/bmc.1402
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record