dc.contributor.author | Pugh, W.J. | |
dc.contributor.author | Wong, R. | |
dc.contributor.author | Falson, F. | |
dc.contributor.author | Michniak, B.B. | |
dc.contributor.author | Moss, G.P. | |
dc.date.accessioned | 2010-09-22T14:27:38Z | |
dc.date.available | 2010-09-22T14:27:38Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Pugh , W J , Wong , R , Falson , F , Michniak , B B & Moss , G P 2005 , ' Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers ' , Journal of Pharmacy and Pharmacology , vol. 57 , no. 11 , pp. 1389-1396 . https://doi.org/10.1211/jpp.57.11.0003 | |
dc.identifier.issn | 0022-3573 | |
dc.identifier.other | PURE: 185528 | |
dc.identifier.other | PURE UUID: 1b2f70e8-ee89-4097-bf19-7b4a5c6a5661 | |
dc.identifier.other | dspace: 2299/4834 | |
dc.identifier.other | Scopus: 34548079772 | |
dc.identifier.uri | http://hdl.handle.net/2299/4834 | |
dc.description | Original article can be found (via Ingenta) at: http://www.ingentaconnect.com/content/0022-3573 Copyright Pharmaceutical Press [Full text of this article is not available in the UHRA] | |
dc.description.abstract | Structure-activity relationships were sought for 73 enhancers of hydrocortisone permeation from propylene glycol across hairless mouse skin. Enhancers had chain lengths (CC) from 0 to 16 carbon atoms, 1 to 8 H-bonding atoms (HB), molecular weight 60 to 450, log P (calculated) −1.7 to 9.7 and log S (calculated) −7.8 to 0.7. These predictive properties were chosen because of their ready availability. Enhancement ratio (ER) was defined as hydrocortisone transferred after 24 h relative to control. Values for the ER ranged from 0.2 to 25.3. Multiple regression analysis failed to predict activity; ER values for the ‘good’ enhancers (ER>10) were underestimated. Simple guidelines suggested that high ER was associated with CC>12 and HB 2–5. This was refined by multivariate analysis to identify significant predictors. Discriminant analysis using CC, HB, and molecular weight correctly assigned 11 of the 12 ‘good’ enhancers (92%). The incorrectly assigned compound was a known, idiosyncratic Br compound. Seventeen of the 61 ‘poor’ enhancers (28%) were incorrectly assigned but four could be considered marginal (ER>8). The success of this simple approach in identifying potent enhancers suggested its potential in predicting novel enhancer activity. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Pharmacy and Pharmacology | |
dc.title | Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers | en |
dc.contributor.institution | Department of Pharmacy | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | https://doi.org/10.1211/jpp.57.11.0003 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |