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        A potential anti-implantation and spermicidal strategy : Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity

        Author
        Ingram, M.J.
        Zeller, E.
        Moss, G.P.
        Hall, C.E.
        Attention
        2299/4836
        Abstract
        We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties. Read More: http://informahealthcare.com/doi/abs/10.1080/13625180600907487
        Publication date
        2006
        Published in
        European Journal of Contraception and Reproductive Healthcare
        Published version
        https://doi.org/10.1080/13625180600907487
        Other links
        http://hdl.handle.net/2299/4836
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