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        Metabolism of captopril carboxyl ester derivatives for percutaneous absorption

        Author
        Gullick, D.R.
        Ingram, M.J.
        Pugh, W.J.
        Cox, P.A.
        Gard, P.
        Smart, J.D.
        Moss, G.P.
        Attention
        2299/4840
        Abstract
        To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare the angiotensin converting enzyme inhibitory potency of the derivatives compared with the parent drug, captopril.
        Publication date
        2009
        Published in
        Journal of Pharmacy and Pharmacology
        Published version
        https://doi.org/10.1211/jpp/61.02.0004
        Other links
        http://hdl.handle.net/2299/4840
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