Metabolism of captopril carboxyl ester derivatives for percutaneous absorption
Author
Gullick, D.R.
Ingram, M.J.
Pugh, W.J.
Cox, P.A.
Gard, P.
Smart, J.D.
Moss, G.P.
Attention
2299/4840
Abstract
To determine the metabolism of captopril n-carboxyl derivatives and how this may impact on their use as transdermal prodrugs. The pharmacological activity of the ester derivatives was also characterised in order to compare the angiotensin converting enzyme inhibitory potency of the derivatives compared with the parent drug, captopril.