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dc.contributor.authorBunn, Frances
dc.contributor.authorRoberts, I.
dc.contributor.authorTasker, R.
dc.date.accessioned2011-01-20T15:58:56Z
dc.date.available2011-01-20T15:58:56Z
dc.date.issued2004
dc.identifier.citationBunn , F , Roberts , I & Tasker , R 2004 , ' Hypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patients ' , Cochrane Database of Systematic Reviews , no. 3 , CD002045 . https://doi.org/10.1002/14651858.CD002045.pub2
dc.identifier.issn1469-493X
dc.identifier.otherPURE: 135013
dc.identifier.otherPURE UUID: 8031ac52-ade8-4dcc-8cf3-14c0214ee8de
dc.identifier.otherdspace: 2299/5207
dc.identifier.otherScopus: 16544392682
dc.identifier.urihttp://hdl.handle.net/2299/5207
dc.descriptionOriginal article can be found at: http://www3.interscience.wiley.com Copyright John Wiley & Sons. ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2004, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Bunn, F. , Roberts, I. and Tasker, R. (2004) 'Hypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patients.' Cochrane Database Systematic Reviews (3) CD002045 http://dx.doi.org/10.1002/14651858.CD002045.pub2
dc.description.abstractBackground: Hypertonic solutions are considered to have a greater ability to expand blood volume and thus elevate blood pressure and can be administered as a small volume infusion over a short time period. On the other hand, the use of hypertonic solutions for volume replacement may also have important disadvantages. Objectives: To determine whether hypertonic crystalloid decreases mortality in patients with hypovolaemia. Search strategy: We searched the Cochrane Injuries Group's specialised register, MEDLINE, EMBASE, The Cochrane Library, issue 3, 2007, The National Research Register issue 3, 2007 and the British Library's Electronic Table of Contents ZETOC. We also checked reference lists of all articles identified. The searches were last updated in October 2007 Selection criteria: Randomised trials comparing hypertonic to isotonic and near isotonic crystalloid in patients with trauma or burns or who were undergoing surgery. Data collection and analysis: Two authors independently extracted the data and assessed the quality of the trials. Main results: Fourteen trials with a total of 956 participants are included in the meta-analysis. The pooled relative risk (RR) for death in trauma patients was 0.84 (95% confidence interval [CI] 0.69 to1.04); in patients with burns 1.49 (95% CI 0.56 to 3.95); and in patients undergoing surgery 0.51 (95% CI 0.09 to 2.73). In the one trial that gave data on disability using the Glasgow outcome scale, the relative risk for a poor outcome was 1.00 (95% CI 0.82 to 1.22). Authors' conclusions: This review does not give us enough data to be able to say whether hypertonic crystalloid is better than isotonic and near isotonic crystalloid for the resuscitation of patients with trauma or burns, or those undergoing surgery. However, the confidence intervals are wide and do not exclude clinically significant differences. Further trials which clearly state the type and amount of fluid used and that are large enough to detect a clinically important difference are needed.en
dc.format.extent26
dc.language.isoeng
dc.relation.ispartofCochrane Database of Systematic Reviews
dc.rightsOpen
dc.titleHypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patientsen
dc.contributor.institutionDepartment of Adult Nursing and Primary Care
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Health and Social Work
dc.contributor.institutionCentre for Research in Public Health and Community Care
dc.contributor.institutionEvidence Based Practice
dc.contributor.institutionNursing, Midwifery and Social Work
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Health and Social Work
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2004
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1002/14651858.CD002045.pub2
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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