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dc.contributor.authorPerel, P.
dc.contributor.authorYanagawa, T.
dc.contributor.authorBunn, Frances
dc.contributor.authorRoberts, I.
dc.contributor.authorWentz, R.
dc.contributor.authorPierro, A.
dc.date.accessioned2011-01-27T11:43:29Z
dc.date.available2011-01-27T11:43:29Z
dc.date.issued2004
dc.identifier.citationPerel , P , Yanagawa , T , Bunn , F , Roberts , I , Wentz , R & Pierro , A 2004 , ' Nutritional support for head-injured patients ' , Cochrane Database of Systematic Reviews , no. 3 , CD001530 . https://doi.org/10.1002/14651858.CD001530.pub2
dc.identifier.issn1469-493X
dc.identifier.otherPURE: 135040
dc.identifier.otherPURE UUID: 69bc8c4e-4700-49d0-b29f-62a9c440d306
dc.identifier.otherdspace: 2299/5244
dc.identifier.urihttp://hdl.handle.net/2299/5244
dc.descriptionCopyright John Wiley & Sons. This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2004, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Perel, P. , Yanagawa, T. , Bunn, F. , Roberts, I. , Wentz, R. and Pierro, A. Nutritional support for head-injured patients. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.: CD001530. DOI: 10.1002/14651858.CD001530.pub2
dc.description.abstractBackground: Head injury increases the body's metabolic responses, and therefore nutritional demands. Provision of an adequate supply of nutrients is associated with improved outcome. The best route for administering nutrition (parenterally (TPN) or enterally (EN)), and the best timing of administration (for example, early versus late) of nutrients needs to be established. Objectives: To quantify the effect on mortality and morbidity of alternative strategies of providing nutritional support following head injury. Search strategy: Trials were identified by computerised searches of the Cochrane Injuries Group specialised register, Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, National Research Register, Web of Science and other electronic trials registers. Reference lists of trials and review articles were checked. The searches were last updated in July 2006. Selection criteria: Randomised controlled trials of timing or route of nutritional support following acute traumatic brain injury. Data collection and analysis: Two authors independently abstracted data and assessed trial quality. Information was collected on death, disability, and incidence of infection. If trial quality was unclear, or if there were missing outcome data, trialists were contacted in an attempt to get further information. Main results: A total of 11 trials were included. Seven trials addressed the timing of support (early versus delayed), data on mortality were obtained for all seven trials (284 participants). The relative risk (RR) for death with early nutritional support was 0.67 (95% CI 0.41 to 1.07). Data on disability were available for three trials. The RR for death or disability at the end of follow-up was 0.75 (95% CI 0.50 to 1.11). Seven trials compared parenteral versus enteral nutrition. Because early support often involves parenteral nutrition, three of the trials are also included in the previous analyses. Five trials (207 participants) reported mortality. The RR for mortality at the end of follow-up period was 0.66 (0.41 to 1.07). Two trials provided data on death and disability. The RR was 0.69 (95% Cl 0.40 to 1.19). One trial compared gastric versus jejunal enteral nutrition, there were no deaths and the RR was not estimable. Authors' conclusions: This review suggests that early feeding may be associated with a trend towards better outcomes in terms of survival and disability. Further trials are required. These trials should report not only nutritional outcomes but also the effect on death and disability.en
dc.format.extent25
dc.language.isoeng
dc.relation.ispartofCochrane Database of Systematic Reviews
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectNursing
dc.titleNutritional support for head-injured patientsen
dc.contributor.institutionDepartment of Adult Nursing and Primary Care
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Health and Social Work
dc.contributor.institutionCentre for Research in Public Health and Community Care
dc.contributor.institutionEvidence Based Practice
dc.contributor.institutionNursing, Midwifery and Social Work
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Health and Social Work
dc.description.versiontypeFinal Published version
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1002/14651858.CD001530.pub2
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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