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dc.contributor.authorEcheverry, M.B.
dc.contributor.authorHasenoehrl, R.
dc.contributor.authorHuston, J.P.
dc.contributor.authorTomaz, C.
dc.identifier.citationEcheverry , M B , Hasenoehrl , R , Huston , J P & Tomaz , C 2001 , ' Comparison of neurokinin SP with diazepam in effects on memory and fear parameters in the elevated T-maze free exploration paradigm ' , Peptides , vol. 22 , no. 7 , pp. 1031-1036 .
dc.identifier.otherPURE: 126051
dc.identifier.otherPURE UUID: f4e9f543-00db-4dea-925a-91c28b0a9d24
dc.identifier.otherdspace: 2299/5292
dc.identifier.otherScopus: 0034974551
dc.descriptionOriginal article can be found at: Copyright Elsevier Inc. [Full text of this article is not availabe in the UHRA]
dc.description.abstractThe elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoidance and open arm escape in one continuous session. Retention of the different fear-responses is measured 72 h later without drug treatment. In order to assess the effects of two known anxiolytics in this paradigm, rats received an IP injection of diazepam (1 to 4 mg/kg), substance P (5 to 500 μg/kg) or vehicle (1 ml/kg) and were tested on the T-maze for 5 min. Diazepam elevated open arm activity, indicative of an anxiolytic effect. The drug also increased the latency to escape from the open arms, but did not significantly affect acquisition of open arm avoidance. During the retention trial, diazepam in higher doses impaired the performance of both fear-responses, suggestive of an anterograde amnesic effect. Substance P did not influence acquisition and retention of open arm avoidance and escape. However, in high doses, the peptide increased the sojourn time in the central arena of the maze, indicating reduced fear and, hence, a dissociation between anxiolytic and amnesic effects. The present findings demonstrate that the elevated T-maze free exploration paradigm is sensitive to anxiolytic and memory-modulating effects of drugs.en
dc.subjectelevated T-maze
dc.subjectconditioned fear
dc.subjectunconditioned fear
dc.subjectemotional reactivity
dc.titleComparison of neurokinin SP with diazepam in effects on memory and fear parameters in the elevated T-maze free exploration paradigmen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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