dc.contributor.author | Voits, M. | |
dc.contributor.author | Hasenoehrl, R. | |
dc.contributor.author | Huston, J.P. | |
dc.contributor.author | Fink, H. | |
dc.date.accessioned | 2011-02-07T14:40:39Z | |
dc.date.available | 2011-02-07T14:40:39Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Voits , M , Hasenoehrl , R , Huston , J P & Fink , H 2001 , ' Repeated treatment with cholecystokinin octapeptide improves maze performance in aged Fischer 344 rats ' , Peptides , vol. 22 , no. 8 , pp. 1325-1330 . https://doi.org/10.1016/S0196-9781(01)00459-4 | |
dc.identifier.issn | 0196-9781 | |
dc.identifier.other | PURE: 122460 | |
dc.identifier.other | PURE UUID: f40b05b2-ece4-40e6-95a8-a4d7a44c686a | |
dc.identifier.other | dspace: 2299/5303 | |
dc.identifier.other | Scopus: 0034895546 | |
dc.identifier.uri | http://hdl.handle.net/2299/5303 | |
dc.description | Original article can be found at: http://www.sciencedirect.com Copyright Elsevier Inc. [Full text of this article is not available in the UHRA] | |
dc.description.abstract | Previous studies have shown that sulfated cholecystokinin octapeptide (CCK-8S) can improve learning in adult rodents when administered systemically or into the central nucleus of amygdala. Here we analyzed the effect of repeated intraperitoneal (i.p.) injection of CCK-8S on the performance of 26-month-old Fischer 344 rats in different versions of the Morris water maze and in a rota-rod test of motor coordination. Old rats were injected daily with different doses of CCK-8S (0.32 to 8.0 μg/kg; IP) 10 min before the behavioral tests. Control groups included vehicle-injected old and adult (3-month-old) F 344 rats. To control for a possible development of tolerance to the behavioral effects of repeated CCK-8S administration, groups of aged rats were included which were subjected to an acute rather than a repeated CCK injection schedule. The repeated administration of CCK-8S did not influence the performance of the old rats in the hidden-platform version of the maze. In addition, the acute treatment with CCK-8S failed to modify navigation performance in this task, suggesting that drug-tolerance may not account for the lack of behavioral effects seen after repeated CCK-8S injection. During the ‘probe trial’, the percentage of animals per group, which swam exactly across the former platform site, was markedly increased in aged rats treated repeatedly with 1.6 μg/kg CCK-8S. This might be indicative of improved retention of the prior platform location and/or a higher resistance of the learned escape response to extinction. The specificity of the effect of CCK-8S on processes related to spatial learning and memory is supported by the lack of effect on motor performance. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Peptides | |
dc.subject | CCK-8S | |
dc.subject | learning | |
dc.subject | memory | |
dc.subject | water maze | |
dc.subject | motor coordination | |
dc.subject | rota-rod | |
dc.subject | old rat | |
dc.title | Repeated treatment with cholecystokinin octapeptide improves maze performance in aged Fischer 344 rats | en |
dc.contributor.institution | Department of Human and Environmental Sciences | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | https://doi.org/10.1016/S0196-9781(01)00459-4 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |