dc.contributor.author | Moddaresi, Mojgan | |
dc.contributor.author | Brown, Marc | |
dc.contributor.author | Tamburic, Slobodanka | |
dc.contributor.author | Jones, Stuart A. | |
dc.date.accessioned | 2011-03-08T10:22:41Z | |
dc.date.available | 2011-03-08T10:22:41Z | |
dc.date.issued | 2010-06 | |
dc.identifier.citation | Moddaresi , M , Brown , M , Tamburic , S & Jones , S A 2010 , ' Tocopheryl acetate disposition in porcine and human skin when administered using lipid nanocarriers ' , Journal of Pharmacy and Pharmacology , vol. 62 , no. 6 , pp. 762-769 . https://doi.org/10.1211/jpp/62.06.0013 | |
dc.identifier.issn | 0022-3573 | |
dc.identifier.other | dspace: 2299/5443 | |
dc.identifier.uri | http://hdl.handle.net/2299/5443 | |
dc.description | The definitive version can be found at: http://www3.interscience.wiley.com/ Copyright Royal Pharmaceutical Society [Full text of this article is not available in the UHRA] | |
dc.description.abstract | Objectives: Assessing the delivery of a drug into the skin when it has been formulated within a nanocarrier is a complex process that does not conform to the conventions of traditional semi-solid formulations. The aim of this study was to gain a fundamental understanding of drug disposition in both human and porcine skin when applied using a lipidic nanocarrier. Methods: A model system was generated by loading tocopheryl acetate into a well-characterised solid lipid nanoparticle and formulating this system as a traditional aqueous hyaluronic acid gel. Franz diffusion cells fitted with a silicone or nylon membrane were used to assess drug and particle transport independently whilst human and pig skin were employed to determine skin delivery. Key findings: The tocopheryl acetate, when loaded into the solid lipid nanoparticles, did not release from the particle. However, 1.65 ± 0.90% of an infinite dose of tocopheryl acetate penetrated into the stratum corneum of pig skin when delivered using a nanoparticle-containing gel. Conclusions: These results suggest that hydration of the stratum corneum in pig skin could lead to the opening of hydrophilic pores big enough for 50 nm-sized particles to pass into the superficial layers of the skin, a phenomenon that was not repeated in human skin. | en |
dc.format.extent | 8 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Pharmacy and Pharmacology | |
dc.subject | human skin | |
dc.subject | nanoparticles | |
dc.subject | percutaneous absorption | |
dc.subject | pig skin | |
dc.subject | tocopheryl acetate | |
dc.subject | vitamin E | |
dc.subject | INVITRO PERCUTANEOUS-ABSORPTION | |
dc.subject | VITAMIN-E | |
dc.subject | IN-VITRO | |
dc.subject | NANOPARTICLES | |
dc.subject | PERMEATION | |
dc.subject | MEMBRANES | |
dc.subject | MODEL | |
dc.subject | PERMEABILITY | |
dc.subject | STABILITY | |
dc.subject | DIFFUSION | |
dc.title | Tocopheryl acetate disposition in porcine and human skin when administered using lipid nanocarriers | en |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1211/jpp/62.06.0013 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |