Show simple item record

dc.contributor.authorFiala, Sarah
dc.contributor.authorJones, Stuart A.
dc.contributor.authorBrown, Marc
dc.date.accessioned2011-03-17T14:46:28Z
dc.date.available2011-03-17T14:46:28Z
dc.date.issued2010-06-30
dc.identifier.citationFiala , S , Jones , S A & Brown , M 2010 , ' A fundamental investigation into the effects of eutectic formation on transmembrane transport ' , International Journal of Pharmaceutics , vol. 393 , no. 1-2 , pp. 68-73 . https://doi.org/10.1016/j.ijpharm.2010.04.001
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 183116
dc.identifier.otherPURE UUID: 4ec79008-0260-4336-9bd8-cf76875cfbd5
dc.identifier.otherdspace: 2299/5501
dc.identifier.otherWOS: 000279208700008
dc.identifier.otherScopus: 77953360376
dc.identifier.urihttp://hdl.handle.net/2299/5501
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/ Copyright Elsevier [Full text of this article is not available in the UHRA]
dc.description.abstractEutectic systems enhance the permeation of therapeutic agents across biological barriers, but the mechanism by which this occurs has not previously been elucidated. Using human skin it has proven difficult to isolate the fundamental effects of eutectic formation on molecule diffusion and partition from those that arise as a consequence of the simultaneous application of two agents. The aim of this work was to employ a model hydrophobic membrane to understand the fundamental permeation characteristics of two agents when applied as a eutectic mixture. Lidocaine and prilocaine were selected as model agents and infinite-dose permeation studies were carried out using pre-calibrated Franz diffusion cells with two thicknesses of silicone membrane. Membrane solubility was determined by HCl solution extraction and the membrane diffusion coefficients were calculated from the permeation lag-times. The maximum permeation enhancement was achieved using a eutectic mixture at a 0.7:0.3 prilocaine/lidocaine ratio. A higher solubility of both agents in silicone membrane, enhanced diffusivity of prilocaine and superior release of both drugs, all contributed to produce enhanced permeation from the eutectic mixtures. Deconvolution of the transmembrane transport process suggests that the eutectic enhancement phenomena is a consequence of more favorable permeation characteristics of the two molecules in the absence of a formulation vehicle which competes in the transport process. (c) 2010 Elsevier B.V. All rights reserved.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectEutectic
dc.subjectPermeation
dc.subjectSilicone membrane
dc.subjectLidocaine
dc.subjectPrilocaine
dc.subjectPREMATURE EJACULATION
dc.subjectTRANSDERMAL DELIVERY
dc.subjectDRUG
dc.subjectLIDOCAINE
dc.subjectPRILOCAINE
dc.subjectPERMEATION
dc.subjectMEMBRANES
dc.subjectMIXTURE
dc.subjectSYSTEMS
dc.subjectSOLUBILITY
dc.titleA fundamental investigation into the effects of eutectic formation on transmembrane transporten
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2010-06-30
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2010.04.001
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record