Show simple item record

dc.contributor.authorSingh, D.K.
dc.contributor.authorWinocour, P.
dc.contributor.authorFarrington, Ken
dc.date.accessioned2011-04-19T12:38:10Z
dc.date.available2011-04-19T12:38:10Z
dc.date.issued2011
dc.identifier.citationSingh , D K , Winocour , P & Farrington , K 2011 , ' Oxidative stress in early diabetic nephropathy : fuelling the fire ' , Nature Reviews Endocrinology , vol. 7 , no. 3 , pp. 176-184 . https://doi.org/10.1038/nrendo.2010.212
dc.identifier.issn1759-5029
dc.identifier.otherPURE: 130444
dc.identifier.otherPURE UUID: 424df199-bf1e-46f2-a266-47a6d12cbcd0
dc.identifier.otherdspace: 2299/5668
dc.identifier.otherScopus: 79952186370
dc.identifier.urihttp://hdl.handle.net/2299/5668
dc.descriptionOriginal article is available at : http://www.nature.com/ Copyright Nature Publishing Group [Full text of this article is not available in the UHRA]
dc.description.abstractDiabetic nephropathy is a major microvascular complication of diabetes mellitus and the most common cause of end-stage renal disease worldwide. The treatment costs of diabetes mellitus and its complications represent a huge burden on health-care expenditures, creating a major need to identify modifiable factors concerned in the pathogenesis and progression of diabetic nephropathy. Chronic hyperglycemia remains the primary cause of the metabolic, biochemical and vascular abnormalities in diabetic nephropathy. Promotion of excessive oxidative stress in the vascular and cellular milieu results in endothelial cell dysfunction, which is one of the earliest and most pivotal metabolic consequences of chronic hyperglycemia. These derangements are caused by excessive production of advanced glycation end products and free radicals and by the subjugation of antioxidants and antioxidant mechanisms. An increased understanding of the role of oxidative stress in diabetic nephropathy has lead to the exploration of a number of therapeutic strategies, the success of which has so far been limited. However, judicious and timely use of current therapies to maintain good glycemic control, adequate blood pressure and lipid levels, along with lifestyle measures such as regular exercise, optimization of diet and smoking cessation, may help to reduce oxidative stress and endothelial cell dysfunction and retard the progression of diabetic nephropathy until more definitive therapies become available.en
dc.language.isoeng
dc.relation.ispartofNature Reviews Endocrinology
dc.titleOxidative stress in early diabetic nephropathy : fuelling the fireen
dc.contributor.institutionCentre for Postgraduate Medicine
dc.contributor.institutionPostgraduate Medicine
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionPharmacology and Clinical Science Research
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1038/nrendo.2010.212
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record