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dc.contributor.authorSingh, D.K.
dc.contributor.authorWinocour, P.
dc.contributor.authorSummerhayes, B.
dc.contributor.authorViljoen, A.
dc.contributor.authorSivakumar, G.
dc.contributor.authorFarrington, Ken
dc.date.accessioned2011-04-19T14:34:45Z
dc.date.available2011-04-19T14:34:45Z
dc.date.issued2009
dc.identifier.citationSingh , D K , Winocour , P , Summerhayes , B , Viljoen , A , Sivakumar , G & Farrington , K 2009 , ' Are low erythropoietin and 1,25-dihydroxyvitamin D levels indicative of tubulo-interstitial dysfunction in diabetes without persistent microalbuminuria? ' , Diabetes Research and Clinical Practice , vol. 85 , no. 3 , pp. 258-264 . https://doi.org/10.1016/j.diabres.2009.06.022
dc.identifier.issn0168-8227
dc.identifier.otherPURE: 131014
dc.identifier.otherPURE UUID: 52df5bec-3b80-427e-a422-a66789ded96c
dc.identifier.otherdspace: 2299/5678
dc.identifier.otherScopus: 68249102138
dc.identifier.urihttp://hdl.handle.net/2299/5678
dc.descriptionOriginal article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]
dc.description.abstractAims: To investigate the relationship between Erythropoietin (EPO) and 1,25-dihydroxyvitamin D levels, and tubular damage in patients with diabetes mellitus (DM) without persistent microalbuminuria. Methods: We measured serum EPO and 1,25-dihydroxyvitamin D levels and tubular injury markers such as urinary N-acetyl-β-d-glucosaminidase (NAG) and retinol binding protein (RBP) levels in 41 non-diabetic controls, 40 patients with Type 1 and 40 with Type 2 DM. Results: Median serum EPO levels were lower in Type 1 (2.57 mIU/ml: p < 0.001) and Type 2 DM (5.69 mIU/ml: p = 0.044) than in controls (8.76 mIU/ml), though haemoglobin levels did not differ. Median 1,25-dihydroxyvitamin D levels were lower in Type 1 (41.0 pmol/l: p = 0.001) and Type 2 DM (41.8 pmol/l: p = 0.035) than in controls (56.1 pmol/l), though serum creatinine, calcium, phosphate and PTH levels did not differ. Median RBP excretion was higher in Type 2 DM (0.35 mg/l vs. 0.23 mg/l: p = 0.013) than in controls. Median NAG excretion was higher in Type 1 DM (1079 μmol/h vs.1030 μmol/h: p = 0.048) compared to controls. Conclusions: Tubulo-interstitial damage with low levels of EPO and 1,25-dihydroxyvitamin D occurs early in Type 1 and Type 2 DM before persistent microalbuminuria.en
dc.language.isoeng
dc.relation.ispartofDiabetes Research and Clinical Practice
dc.subjecttubulo-interstitium
dc.subjecterythropoietin
dc.subject1,25-dihydroxyvitamin D
dc.subjectN-acetyl-β-d-glucosaminidase
dc.subjectRetinol binding protein
dc.titleAre low erythropoietin and 1,25-dihydroxyvitamin D levels indicative of tubulo-interstitial dysfunction in diabetes without persistent microalbuminuria?en
dc.contributor.institutionCentre for Postgraduate Medicine
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPostgraduate Medicine
dc.contributor.institutionHealth Services and Medicine
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=68249102138&partnerID=8YFLogxK
dcterms.dateAccepted2009
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.diabres.2009.06.022
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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