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dc.contributor.authorFarrington, Ken
dc.contributor.authorRegan, F.
dc.date.accessioned2011-04-20T11:09:12Z
dc.date.available2011-04-20T11:09:12Z
dc.date.issued2009
dc.identifier.citationFarrington , K & Regan , F 2009 , ' Molecularly imprinted sol gel for ibuprofen : an analytical study of the factors influencing selectivity ' Talanta , vol. 78 , no. 3 , pp. 653-659 . https://doi.org/10.1016/j.talanta.2008.12.013
dc.identifier.issn0039-9140
dc.identifier.otherPURE: 130519
dc.identifier.otherPURE UUID: abeb172b-b5d1-4b44-a9b0-c7c7625d04f8
dc.identifier.otherdspace: 2299/5682
dc.identifier.otherScopus: 61449205983
dc.identifier.urihttp://hdl.handle.net/2299/5682
dc.descriptionOriginal article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]
dc.description.abstractThis paper describes the preparation and testing of a sol gel specific for the non-steroidal anti-inflammatory drug ibuprofen. Ibuprofen was selected as a model compound due to the fact that it contains a number of structural and functional analogues, in this case ketoprofen and naproxen. In order to study the specific criteria affecting selectivity in sol gels, three sol gels were prepared for ibuprofen utilising two and three functional silane systems. The relative rebinding of each of the three compounds to the sol gels was assessed by % recovery in solid phase extraction. The results of the experiments indicate that along with the functionality imparted to the sol gel by the development of template-monomer complexes a major determinant of selectivity is shape selective memory. The utilisation of a three monomer system affords the cavity recognition based on the formation of π–π stacking interactions, hydrogen bonding, van der Waals forces, electrostatic interactions and shape complementarity and minimises cross reactivity. In addition real sample analysis has been performed on urine samples containing ibuprofen and metabolites showing specific preconcentration.en
dc.language.isoeng
dc.relation.ispartofTalanta
dc.subjectmolecularly imprinted sol gels
dc.subjectibuprofen
dc.subjectsolid phase extraction
dc.subjectswelling/shrinkage
dc.subjectshape selectivity
dc.titleMolecularly imprinted sol gel for ibuprofen : an analytical study of the factors influencing selectivityen
dc.contributor.institutionCentre for Postgraduate Medicine
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.talanta.2008.12.013
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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