Show simple item record

dc.contributor.authorBalasubramaniam, G.
dc.contributor.authorBrown, E.A.
dc.contributor.authorDavenport, A.
dc.contributor.authorCairns, H.
dc.contributor.authorCooper, B.
dc.contributor.authorFan, S.L.
dc.contributor.authorFarrington, Ken
dc.contributor.authorGallagher, H.
dc.contributor.authorHarnett, P.
dc.contributor.authorKrausze, S.
dc.contributor.authorSteddon, S.
dc.identifier.citationBalasubramaniam , G , Brown , E A , Davenport , A , Cairns , H , Cooper , B , Fan , S L , Farrington , K , Gallagher , H , Harnett , P , Krausze , S & Steddon , S 2009 , ' The Pan-Thames EPS study : treatment and outcomes of encapsulating peritoneal sclerosis ' , Nephrology Dialysis Transplantation , vol. 24 , no. 10 , pp. 3209-3215 .
dc.identifier.otherPURE: 130406
dc.identifier.otherPURE UUID: 1432cc50-880f-4176-bb93-6db89cf2d030
dc.identifier.otherdspace: 2299/5683
dc.identifier.otherScopus: 70349510211
dc.descriptionOriginal article can be found at : Copyright Oxford University Press [Full text of this article is not available in the UHRA]
dc.description.abstractBackground: Encapsulating peritoneal sclerosis (EPS) is a disease process that can occur as a complication of peritoneal dialysis (PD). The aim of this study was to make a general assessment of the clinical features, diagnosis, management and outcome of PD-related EPS cases from London and South-East England. Methods: Questionnaires were sent to 11 PD units in March 2007; cases were identified retrospectively. Outcome data on surviving patients were collected in March 2008. Results: A total of 111 patients were identified; the mean time on PD was 82 months (range 8–247). Mortality increased with length of time on PD, being 42% at <3 years (n = 12), 32% at 3–4 years (n = 19), 61% at 5–6 years (n = 31), 54% at 7–8 years (n = 24), 75% at 9–10 years (n = 8) and 59% at >10 years (n = 17). Twelve patients had no previous peritonitis episodes, 28 had one previous episode, 30 had two previous episodes and 33 had three or more previous episodes. Of the patients with PD details available, 41/63 were high (>0.81) transporters and 44/71 had ultrafiltration <1 l/24 h, but 7/63 were low average transporters (0.5–<0.65) and 27/71 had ultrafiltration >1 l/24 h and a few had significant residual renal function. Sixty-five (59%) patients had their PD discontinued prior to diagnosis (51 HD; 14 transplanted). CT scans were performed on 91 patients and laparotomy on 47 patients. Drug treatment consisted of tamoxifen, immunosuppression or both. The median survival was 15 months in patients treated with tamoxifen (n = 17), 12 months in patients treated with immunosuppression (n = 24) and 21 months in patients who received both (n = 13), against 13 months (n = 46) in patients who received no specific treatment. Adhesionolysis was performed in 5 patients, and 39 patients were given parenteral nutrition. The overall mortality was 53% with a median survival of 14 months and a median time to death of 7 months. Conclusion: This is one of the largest cohorts of patients with EPS in the literature. Long-term survival occurred in over 50%, regardless of the various treatments strategies undertaken by the centres.en
dc.relation.ispartofNephrology Dialysis Transplantation
dc.subjectencapsulating peritoneal sclerosis
dc.subjectperitoneal dialysis
dc.subjectmulticentre retrospective study
dc.titleThe Pan-Thames EPS study : treatment and outcomes of encapsulating peritoneal sclerosisen
dc.contributor.institutionCentre for Postgraduate Medicine
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record