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dc.contributor.authorViljoen, A.
dc.contributor.authorSingh, D.K.
dc.contributor.authorTwomey, P.J.
dc.contributor.authorFarrington, Ken
dc.identifier.citationViljoen , A , Singh , D K , Twomey , P J & Farrington , K 2008 , ' Analytical quality goals for parathyroid hormone based on biological variation ' , Clinical Chemistry and Laboratory Medicine , vol. 46 , no. 10 , pp. 1438-1442 .
dc.identifier.otherPURE: 131061
dc.identifier.otherPURE UUID: b8e02949-f049-4a06-b966-27fe3efda20a
dc.identifier.otherdspace: 2299/5687
dc.identifier.otherScopus: 53849127153
dc.descriptionOriginal article can be found at : Copyright Walter de Gruyter [Full text of this article is not available in the UHRA]
dc.description.abstractBackground: Measurement of parathyroid hormone (PTH) is central in the investigation of pathologies of bone and mineral ion metabolism. Knowledge of the biological variation of an analyte forms an essential part of evaluating a new analyte, enabling the objective assessment of changes in serial results and the utility of reference intervals, as well as establishing laboratory quality specifications. Methods: This study determined the biological variation of PTH in 20 healthy individuals, which was calculated according to the familiar methods outlined by Fraser and Harris. Results: The within-subject variation was 25.3% and the between-subject variation was 43.4%. The critical difference for sequential values significant at p<0.05 was calculated as 72%. The within-subject variation forms a relatively small part of the reference interval, shown by the low index of individuality of 0.58. Objective analytical quality goals have also been established, revealing achievable optimum performance for imprecision of ~6%. The desirable analytical bias goal was ~12%. Conclusions: This study has objectively shown that the analytical precision of current instruments is being achieved contrary to the known problems surrounding the analytical bias for PTH assays. The limitations of using reference intervals for PTH, both in diagnoses and monitoring, are shown.en
dc.relation.ispartofClinical Chemistry and Laboratory Medicine
dc.titleAnalytical quality goals for parathyroid hormone based on biological variationen
dc.contributor.institutionCentre for Postgraduate Medicine
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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