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dc.contributor.authorReid, Monica L.
dc.contributor.authorJones, Stuart A.
dc.contributor.authorBrown, Marc
dc.date.accessioned2011-05-25T15:13:50Z
dc.date.available2011-05-25T15:13:50Z
dc.date.issued2009-04-17
dc.identifier.citationReid , M L , Jones , S A & Brown , M 2009 , ' Transient drug supersaturation kinetics of beclomethasone dipropionate in rapidly drying films ' , International Journal of Pharmaceutics , vol. 371 , no. 1-2 , pp. 114-119 . https://doi.org/10.1016/j.ijpharm.2008.12.025
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 184308
dc.identifier.otherPURE UUID: 426c7a26-8f99-4518-bed2-edda158a8176
dc.identifier.otherdspace: 2299/5855
dc.identifier.otherWOS: 000265361300015
dc.identifier.otherScopus: 62949219654
dc.identifier.urihttp://hdl.handle.net/2299/5855
dc.descriptionOriginal article can be found at : http://www.sciencedirect.com/ Copyright Elsevier [Full text of this article is not available in the UHRA]
dc.description.abstractSupersaturation is an effective method to enhance the delivery of active compounds into the skin, however the long-term instability of the drug in these formulations that exceed thermodynamic unity prevents clinical use. The creation of supersaturation in situ by volatile solvent evaporation after application may overcome this. The aim of this study was to determine how altering the kinetics of transient supersaturation and recrystallisation would effect the rate of beclomethasone dipropionate (BDP) release from metered dose aerosols (MDA) that also consisted of hydrofluoroalkane 134a, ethanol (EtOH), and poly(vinyl pyrrolidone) (PVP) K90. An MDA containing 10% EtOH generated a sub-saturated concentration of BDP immediately after dose actuation and did not become supersaturated until 30 min post-actuation. Increasing the EtOH to 20% (w/w) and thus the BDP to 1.76% created supersaturation upon dose actuation but the drug recyrstallised within minutes of application. It was shown that the formulations with higher DS had accelerated rates of release despite rapid recrystallisation (444.9 ± 79.3 μg/(cm2 h) for the fastest compared to 206.5 ± 23.0 μg/(cm2 h) for the slowest). In highly volatile sprays maintaining BDP supersaturation for extended periods of time was less important than generating instantaneous, high levels of supersaturation to enhance drug release.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectTopical drug delivery
dc.subjectCorticosteroid
dc.subjectSupersaturation
dc.subjectDiffusion
dc.subjectVITRO MEMBRANE-TRANSPORT
dc.subjectHYDROCORTISONE ACETATE
dc.subjectHUMAN SKIN
dc.subjectIN-VITRO
dc.subjectPENETRATION ENHANCEMENT
dc.subjectDELIVERY SYSTEMS
dc.subjectVAPOR-PRESSURE
dc.subjectCRYSTALLIZATION
dc.subjectEVAPORATION
dc.subjectPOLYMERS
dc.titleTransient drug supersaturation kinetics of beclomethasone dipropionate in rapidly drying filmsen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2009-04-17
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2008.12.025
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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