Show simple item record

dc.contributor.authorTraynor, M.J.
dc.contributor.authorZhao, Yanjun
dc.contributor.authorBrown, Marc
dc.contributor.authorJones, Stuart A.
dc.date.accessioned2011-05-26T17:09:45Z
dc.date.available2011-05-26T17:09:45Z
dc.date.issued2011-05-30
dc.identifier.citationTraynor , M J , Zhao , Y , Brown , M & Jones , S A 2011 , ' Vinyl polymer-coated lorazepam particles for drug delivery to the airways ' , International Journal of Pharmaceutics , vol. 410 , no. 1-2 , pp. 9-16 . https://doi.org/10.1016/j.ijpharm.2011.02.053
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 183796
dc.identifier.otherPURE UUID: d925254d-05d9-4c4e-a31b-0ed5f2ed38ef
dc.identifier.otherdspace: 2299/5858
dc.identifier.otherWOS: 000291138300002
dc.identifier.otherScopus: 79955619106
dc.identifier.otherORCID: /0000-0001-7332-0011/work/32634799
dc.identifier.urihttp://hdl.handle.net/2299/5858
dc.descriptionOriginal article can be found at : http://www.sciencedirect.com/ Copyright Elsevier
dc.description.abstractA particle engineering method that adsorbs a microfine vinyl polymer coat to crystalline drug microparticles has been shown to be an effective way to control delivery. However, the means by which the functional performance of such microparticles is altered by the behaviour of the polymers in the microparticle coat remains unclear. The aim of this study was to determine the influence of vinyl polymer coating on the in vitro delivery characteristics of intranasal lorazepam microparticles. A series of four, similarly sized (ca. 10 μm), lorazepam-rich microparticles with different polymer coats were generated. The absorption of the polymer coats appeared to disrupt lorazepam solid state dimer formation in the microparticles, which manifested in a reduction in drug melting point. Mildly cohesive particles (aerodynamic diameter of 32 μm) that allowed rapid drug release (ca. 80% in 5 min) were generated when partially hydrolysed PVA dominated the microparticle coat, whilst fully hydrolysed PVA reduced particle cohesion and retarded drug release (ca. 15% release in 5 min). Infrared analysis showed that the properties of the microparticles were dictated by the strength of the hydrogen bonding in the polymer coat and not the strength of coat adsorption that was facilitated by hydrogen bond formation between the hydroxyl groups of the PVA and the hydroxyl group at position C3 of the lorazepam diazepine ring.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectLorazepam
dc.subjectIntranasal delivery
dc.subjectCoating
dc.subjectMicroparticles
dc.subjectPoly(vinyl alcohol)
dc.subjectPVP
dc.subjectPOWDER INHALER FORMULATION
dc.subjectNASAL DELIVERY
dc.subjectTECHNOLOGY
dc.subjectINHALATION
dc.subjectMICROPARTICLES
dc.subjectOPTIMIZATION
dc.titleVinyl polymer-coated lorazepam particles for drug delivery to the airwaysen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionToxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2011.02.053
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record