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dc.contributor.authorSaha, P.
dc.contributor.authorStott, D.
dc.contributor.authorAtalla, R.
dc.date.accessioned2011-06-06T14:52:52Z
dc.date.available2011-06-06T14:52:52Z
dc.date.issued2009
dc.identifier.citationSaha , P , Stott , D & Atalla , R 2009 , ' Haemostatic changes in the puerperium '6 weeks postpartum' (HIP Study) — implication for maternal thromboembolism ' , BJOG - an International Journal of Obstetrics and Gynaecology , vol. 116 , no. 12 , pp. 1602-1612 . https://doi.org/10.1111/j.1471-0528.2009.02295.x
dc.identifier.issn1470-0328
dc.identifier.otherPURE: 117429
dc.identifier.otherPURE UUID: decb0505-bf32-407b-8afc-720cede90e4a
dc.identifier.otherdspace: 2299/5913
dc.identifier.otherScopus: 70350120712
dc.identifier.urihttp://hdl.handle.net/2299/5913
dc.descriptionThe definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright Royal College of Obstetricians and Gynaecologists [Full text of this article is not available in the UHRA]
dc.description.abstractObjective : We aim to measure the thrombotic changes during the postnatal period up to 6 weeks after delivery and assess the extent of the risk period. Design : Prospective observational study. Setting : Queen Elizabeth II, an acute District General Hospital, Hertfordshire. Population : Women booked at the antenatal clinic and prepared to deliver at the hospital. Methods : We assessed the haemoglobin, platelet count and function, fibrinogen, prothrombin time, activated partial thromboplastin time, protein C, S and antithrombin level and as well as rotational thromboelastometry (ROTEM) from predelivery till 6 weeks postpartum. Results : A total 50 women were recruited of which four dropped out. Results compared against the finding at 6 weeks after delivery. Platelet was significantly elevated on day 19 compared to day 42 (P < 0.001). Fibrinogen was elevated from predelivery till day 15 after delivery (P < 0.01). Prothrombin time (PT) was low till day 15 (P < 0.05) and activated partial thromboplastin time (APTT) was significantly lower till day 3 after delivery (P < 0.001). ROTEM revealed low clotting time (CT) at predelivery and continued to be low till day 7. Clot formation time (CFT) significantly low till day 25 (P < 0.05). Maximum clot firmness, alpha angle and amplitude at 20 minutes were raised till day 19 (P < 0.001, P < 0.01 and P < 0.001 respectively). While, comparing vaginal delivery against caesarean section there were nonsignificant increase in thrombotic parameters in caesarean section. Conclusion : Coagulation screens as well as thomboelastometry suggest a persistent hypercoagulation during the first 3 weeks after delivery.en
dc.language.isoeng
dc.relation.ispartofBJOG - an International Journal of Obstetrics and Gynaecology
dc.subjecthypercoagulation
dc.subjectmaternal haemostatic change
dc.subjectpostpartum
dc.subjectpuerperium
dc.subjectthromboembolism
dc.titleHaemostatic changes in the puerperium '6 weeks postpartum' (HIP Study) — implication for maternal thromboembolismen
dc.contributor.institutionDepartment of Allied Health Professions and Midwifery
dc.description.statusPeer reviewed
dcterms.dateAccepted2009
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1471-0528.2009.02295.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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