Browsing University of Hertfordshire by Author "Chibalina, Margarita V"

Now showing items 1-4 of 4

    • Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production 

      Knudsen, Jakob G; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V; Spégel, Peter; Mulder, Hindrik; Zhang, Quan; Ashcroft, Frances M; Adam, Julie; Rorsman, Patrik (2019-02-05)
      Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon ...

    • Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells 

      Hastoy, Benoît; Godazgar, Mahdieh; Clark, Anne; Nylander, Vibe; Spiliotis, Ioannis; van de Bunt, Martijn; Chibalina, Margarita V; Barrett, Amy; Burrows, Carla; Tarasov, Andrei I; Scharfmann, Raphael; Gloyn, Anna L; Rorsman, Patrik (2018-11-19)
      Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their ...

    • GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation 

      Shigeto, Makoto; Ramracheya, Reshma; Tarasov, Andrei I; Cha, Chae Young; Chibalina, Margarita V; Hastoy, Benoit; Philippaert, Koenraad; Reinbothe, Thomas; Rorsman, Nils; Salehi, Albert; Sones, William R; Vergari, Elisa; Weston, Cathryn; Gorelik, Julia; Katsura, Masashi; Nikolaev, Viacheslav O; Vennekens, Rudi; Zaccolo, Manuela; Galione, Antony; Johnson, Paul R V; Kaku, Kohei; Ladds, Graham; Rorsman, Patrik (2015-12-01)
      Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...

    • Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion 

      Vergari, Elisa; Knudsen, Jakob G; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J B; Chibalina, Margarita V; Gribble, Fiona M; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J G; Spiliotis, Ioannis I; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M; Rorsman, Patrik (2019-01-11)
      Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels ...