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Browsing University of Hertfordshire by Author "Chilton, C. H."
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Evaluation of the effect of oritavancin on Clostridium difficile spore germination, outgrowth and recovery
Chilton, C. H.; Freeman, J.; Baines, Simon D.; Crowther, G. S.; Nicholson, S.; Wilcox, M. H. (2013)OBJECTIVES: Previous work suggests oritavancin may be inhibitory to Clostridium difficile spores. We have evaluated the effects of oritavancin exposure on C. difficile spore germination, outgrowth and recovery. METHODS: ... -
In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection
Chilton, C. H.; Crowther, G. S.; Baines, Simon D.; Todhunter, S. L.; Freeman, J.; Locher, H. H.; Athanasiou, A.; Wilcox, M. H. (2013-10-14)Abstract Objectives We investigated the in vitro activity of cadazolid against 100 Clostridium difficile isolates and its efficacy in a simulated human gut model of C. difficile infection (CDI). Methods MICs of cadazolid, ... -
In vitro susceptibility of Clostridium difficile to SMT19969 and comparators, as well as the killing kinetics and post-antibiotic effects of SMT19969 and comparators against C. difficile
Corbett, D.; Wise, A.; Birchall, S.; Warn, P.; Baines, Simon D.; Crowther, G.; Freeman, J.; Chilton, C. H.; Vernon, J.; Wilcox, M. H.; Vickers, R. J. (2015-06-01)OBJECTIVES: SMT19969 is a novel antimicrobial under clinical development for the treatment of Clostridium difficile infection (CDI). The objective was to determine the comparative susceptibility of 82 C. difficile clinical ...