Browsing University of Hertfordshire by Author "Choi, Ji-won"

Now showing items 1-2 of 2

    • Disulfide bridge based PEGylation of proteins 

      Brocchini, Steve; Godwin, Antony; Balan, Sibu; Choi, Ji-won; Zloh, Mire; Shaunak, Sunil (2008-01)
      PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation exploits the thiol selective chemistry of the two cysteine sulfur atoms ...

    • Site-specific PEGylation at histidine tags 

      Cong, Yuehua; Pawlisz, Estera; Bryant, Penny; Balan, Sibu; Laurine, Emmanuelle; Tommasi, Rita; Singh, Ruchi; Dubey, Sitara; Peciak, Karolina; Bird, Matthew; Sivasankar, Amrita; Swierkosz, Julia; Muroni, Maurizio; Heidelberger, Sibylle; Farys, Monika; Khayrzad, Farzad; Edwards, Jeff; Badescu, George; Hodgson, Ian; Heise, Charles; Somavarapu, Satyanarayana; Liddell, John; Powell, Keith; Zloh, Mire; Choi, Ji-won; Godwin, Antony; Brocchini, Steve (2012)
      The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based ...