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Browsing University of Hertfordshire by Author "Cuzick, Jack"
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Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas
Stankiewicz, Elzbieta; Prowse, David M.; Ng, Mansum; Cuzick, Jack; Mesher, David; Hiscock, Frances; Lu, Yong Jie; Watkin, Nicholas; Corbishley, Catherine; Lam, Wayne; Berney, Daniel M. (2011-03-10)Background: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood, though risk factors include human papillomavirus (HPV). Disruption of HER/PTEN/Akt pathway is present in many cancers; however ... -
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
Stankiewicz, Elzbieta; Kudahetti, Sakunthala C.; Prowse, David M.; Ktori, Elena; Cuzick, Jack; Ambroisine, Laurence; Zhang, Xiaoxi; Watkin, Nicholas; Corbishley, Catherine; Berney, Daniel M. (2009-09-01)Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series ... -
Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer
Kudahetti, Sakunthala C.; Fisher, Gabrielle; Ambroisine, Laurence; Prowse, David M.; Kattan, Michael W.; Foster, Christopher S.; Møller, Henrik; Oliver, Tim; Fletcher, Anne; Cooper, Colin; Reuter, Victor; Scardino, Peter; Cuzick, Jack; Berney, Daniel M. (2010-10-01)Aims: Treatment decisions are difficult in clinically localised prostate cancer and further biomarkers of aggressive behaviour are required. We investigated the hypothesis that the tissue expression of three cell cycle ... -
International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate : A meta-analysis of 1446 patients
Shaw, Greg L.; Wilson, Peter; Cuzick, Jack; Prowse, David M.; Goldenberg, S. Larry; Spry, Nigel A.; Oliver, Tim (2007-05-01)OBJECTIVE: To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of treating metastatic prostate cancer, and which carries a ... -
The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
Stankiewicz, Elzbieta; Prowse, David M.; Ktori, Elena; Cuzick, Jack; Ambroisine, Laurence; Zhang, Xiaoxi; Kudahetti, Sakunthala; Watkin, Nicholas; Corbishley, Catherine; Berney, Daniel M. (2011-02-01)Aims: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood. Human papillomavirus (HPV) may be involved in carcinogenesis, but few studies have compared cell-cycle protein expression in HPV ...