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Browsing University of Hertfordshire by Author "Goyal, Madhu"
Now showing items 1-11 of 11
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A cellulose-based bioassay for the colorimetric detection of pathogen DNA
Saikrishnan, Deepika; Goyal, Madhu; Rossiter, Sharon; Kukol, A. (2014-12-01)Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen ... -
Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
Genetic Diversity of Mycobacterium tuberculosis Complex Strains Isolated from Patients with Pulmonary Tuberculosis in Anambra State, Nigeria
Uzoewulu, Gertrude; Lawson, Lovett; Nnanna, Ibeh; Rastogi, Nalin; Goyal, Madhu (2017-02-08)In this study, we analyzed Mycobacterium tuberculosis complex (MTC) genetic diversity in Anambra State, Nigeria based on spoligotyping followed by 5-loci exact tandem repeats (ETRs). Spoligotyping of 180 MTC strains isolated ... -
Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
Anagani, Bhavani; Singh, Jagbir; Bassin, Jatinder; Besra, Gurdyal; Benham, Christopher; Reddy, Tummala Rama Krishna; Cox, Jonathan; Goyal, Madhu (2020-05-18)Objectives: The search for new TB drugs has become one of the great challenges for modern medicinal chemistry. An improvement in the outcomes of TB chemotherapy can be achieved by the development of new, shorter, cheap, ... -
The molecular epidemiology of tuberculosis in inner London
Hayward, A.C.; Goss, S.; Dobniewski, F.; Saunders, N.; Shaw, R.J.; Goyal, Madhu; Swan, A.; Uttley, A.; Pozniak, A.; Grace-Parker, J.; Watson, J.M. (2002) -
Synthesis and antibacterial activity of benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide derivatives
Bassin, Jatinder; Botha, Michelle; Garikipati, Rajesh; Goyal, Madhu; Martin, Lee; Shah, Amit (2017-11-04)We have developed a simple and efficient synthetic route, starting from easily available starting materials, to the ring system benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide. A series of chalcones were synthesized which ... -
Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives
Patel, Chandani; Bassin, Jatinder; Scott, Mark; Flye, Jenna; Hunter, Ann; Martin, Lee; Goyal, Madhu (2016-06-30)A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1-9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone ... -
Synthesis and evaluation of antibacterial activity of series of novel diketones
Rossiter, Sharon; Zloh, Mire; Bassin, Jatinder; Singh, Jagbir; Goyal, Madhu (2015-11-26) -
Synthesis and evaluation of chalcones and isobenzofuranones for their antimycobacterial activity.
Anagani, Bhavani; Bassin, Jatinder; Benham, Christopher; Goyal, Madhu (2015-11-26) -
Synthesis and Spectral Characterization of Benzo[6,7] [1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives
Bassin, Jatinder; Anagani, Bhavani; Benham, Christopher; Goyal, Madhu; Hashemian , Maryam; Gerhard, Ute (2016-07-23)A simple synthetic route to benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring system is developed from readily available starting materials 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline ... -
Tuberculin screening of some selected Fulani lactating cows in north-central Nigeria
Abubakar, A.; Alan, L.; Okaiyeto, O.; Kudi, A. C.; Abdullahi, S. U.; Brooks, P. H.; Goyal, Madhu (2013-10)The prevalence of mycobacterial infection among lactating Fulani cows was investigated in the Federal Capital Territory, Abuja and Kaduna State of Nigeria. Tuberculin testing using single comparative intradermal tuberculin ...