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H-1 NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists
Herbert, R. H.; Gerhard, U.; Mortishire-Smith, R. J.; Thomas, S. R.; Hollingworth, G. (2005-08)The binding affinities at the human NK-1 receptor of two spirocyclic compounds were found to be similar despite being epimeric at a key stereocentre. This unexpected result prompted a thorough investigation of the solution ...