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Browsing University of Hertfordshire by Author "Hundhausen, C."
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The disintegrin-like metalloproteinase ADAM 10 is involved in coinstitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
Hundhausen, C.; Misztela, D.; Berkhout, Theo; Broadway, N.; Saftig, P.; Reiss, K.; Hartmann, D.; Fahrenholz, F.; Postina, R.; Matthews, J.; Kallen, K.J.; Rose-John, S.; Ludwig, A. (2003-08-15)The CX3C chemokine fractalkine (CX3CL1) exists as a membrane-expressed protein promoting cell-cell adhesion and as a soluble molecule inducing chemotaxis. Transmembrane CX3CL1 is converted into its soluble form by defined ... -
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10
Abel, S.; Hundhausen, C.; Mentlein, R.; Schulte, A.; Berkhout, Theo; Broadway, N.; Hartmann, D. H.; Sedlacek, R.; Dietrich, S.; Muetze, B.; Schuster, B.; Kallen, K.J.; Saftig, P.; Rose-John, S.; Ludwig, A. (2004-05-15)The novel CXC-chemokine ligand 16 (CXCL16) functions as transmembrane adhesion molecule on the surface of APCs and as a soluble chemoattractant for activated T cells. In this study, we elucidate the mechanism responsible ...