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Browsing University of Hertfordshire by Author "Inal, Jameel M."
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Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy
Inal, Jameel M. (2020-06-16)The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor ... -
Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis
An, Taixue; Qin, Sihua; Xu, Yong; Tang, Yueting; Huang, Yiyao; Situ, Bo; Inal, Jameel M.; Zheng, Lei (2015-06-22)Exosomes, membrane vesicles of 40-100 nm in diameter, are derived from endosomes in various cells. The bioactive molecules specifically packed into exosomes can be horizontally transferred into recipient cells changing ... -
Low Magnetic Field Exposure Alters Prostate Cancer Cell Properties
Lange, Sigrun; Inal, Jameel M.; Kraev, Igor; Dart, Dafydd Alwyn; Uysal-Onganer, Pinar (2024-09-19)Simple Summary: The effects of magnetic fields on health and disease have been subject to considerable research interest for the past few decades but still remain relatively poorly understood. Therefore, the identification ... -
A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
Kholia, Sharad; Jorfi, Samireh; Thompson, Paul R.; Causey, Corey P.; Nicholas, Anthony P.; Inal, Jameel M.; Lange, Sigrun (2015-06-22)Introduction: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and ... -
A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species
Inal, Jameel M.; Hristova, Mariya; Lange, Sigrun (2022-08-04)PADs are a group of calcium-dependent enzymes that play key roles in inflammatory pathologies and have diverse roles in cancers. PADs cause irreversible post-translational modification of arginine to citrulline, leading ...