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Browsing University of Hertfordshire by Author "McNulty, S."
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Amyloid β-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures
Fonfria, E.; Marshall, I.C.B.; Boyfield, I.; Skaper, S.D.; Hughes, J.P.; Owen, D.; Zhang, W.; Miller, B.A.; Benham, C.D.; McNulty, S. (2005)Amyloid β-peptide (Aβ) is the main component of senile plaques which characterize Alzheimer's disease and may induce neuronal death through mechanisms which include oxidative stress. To date, the signalling pathways linking ... -
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurons
Hill, K.; Tigue, N.; Kelsell, R.E.; Benham, C.D.; McNulty, S.; Schaefer, M.; Randall, A.D. (2006)TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and ... -
Flufenamic acid is a pH-dependent antagonist of TRPM2 channels
Hill, K.; Benham, C.D.; McNulty, S.; Randall, A.D. (2004)Like a number of other TRP channels, TRPM2 is a Ca2+-permeable non-selective cation channel, the activity of which is regulated by intracellular and extracellular Ca2+. A unique feature of TRPM2 is its activation by ... -
Tissue distribution profiles of the human TRPM cation channel family
Fonfria, E.; Murdock, P.; Cusdin, F.S.; Benham, C.D.; Kelsell, R.E.; McNulty, S. (2006) -
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase
Fonfria, E.; Marshall, I.C.B.; Benham, C.D.; Boyfield, I.; Brown, J.D.; Hill, K.; Hughes, J.P.; Kelsell, R.E.; Skaper, S.D.; Scharenberg, A.M.; McNulty, S. (2004) -
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia
Fonfria, E.; Mattei, C.; Hill, K.; Brown, J.T.; Randall, A.D.; Benham, C.D.; Skaper, S.D.; Campbell, C.A.; Crook, B.; Murdoch, P.R.; Wilson, J.M.; Murio, F.P.; Owen, D.; Tilling, P.L.; McNulty, S. (2006)We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle ...