Browsing University of Hertfordshire by Author "Mondhe, Madhav"

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    • Species-selective killing of bacteria by antimicrobial peptide-PNAs 

      Mondhe, Madhav; Chessher, Ashley; Goh, Shan; Good, Liam; Stach, James E M (2014-02-18)
      Broad-spectrum antimicrobials kill indiscriminately, a property that can lead to negative clinical consequences and an increase in the incidence of resistance. Species-specific antimicrobials that could selectively kill ...

    • Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) 

      Uguru, Gabriel C; Mondhe, Madhav; Goh, Shan; Hesketh, Andrew; Bibb, Mervyn J; Good, Liam; Stach, James E M (2013-06-27)
      We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic ...