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Browsing University of Hertfordshire by Author "Nicholas, Anthony P."
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A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
Kholia, Sharad; Jorfi, Samireh; Thompson, Paul R.; Causey, Corey P.; Nicholas, Anthony P.; Inal, Jameel M.; Lange, Sigrun (2015-06-22)Introduction: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and ... -
Peptidylarginine deiminase inhibitors reduce bacterial membrane vesicle release and sensitize bacteria to antibiotic treatment
Kosgodage, Uchini S; Matewele, Paul; Mastroianni, Giulia; Lange, Sigrun; Kraev, Igor; Brotherton, Dominik; Awamaria, Brigitte; Nicholas, Anthony P.; Inal, Jameel (2019-06-27)Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically ... -
Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme
Kosgodage, Uchini S; Uysal-Onganer, Pinar; MacLatchy, Amy; Kraev, Igor; Chatterton, Nicholas; Nicholas, Anthony P.; Inal, Jameel; Lange, Sigrun (2018-12-28)Glioblastoma multiforme (GBM) is the most aggressive form of adult primary malignant brain tumour with poor prognosis. Extracellular vesicles (EVs) are a key-mediator through which GBM cells promote a pro-oncogenic ...