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Browsing University of Hertfordshire by Author "Rice-Evans, Catherine"
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Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
Vauzour, David; Vafeiadou, Katerina; Rice-Evans, Catherine; Williams, Robert J.; Spencer, Jeremy P. E. (2007-11)There is growing interest in the potential beneficial effects of flavonoids in the aging and diseased brain. We have investigated the potential of the flavanone hesperetin and two of its metabolites, hesperetin-7-O-beta- ... -
Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway
Vauzour, David; Vafeiadou, Katerina; Rice-Evans, Catherine; Cadenas, Enrique; Spencer, Jeremy P. E. (2007-12-15)The cellular actions of genistein, and its in vivo metabolites, are believed to mediate the decreased risk of breast cancer associated with high soy consumption. The genistein metabolite, 5,7,3',4'-tetrahydroxyisoflavone ... -
The reaction of flavonoid metabolites with peroxynitrite
Pollard, Susan E.; Kuhnle, Gunter G. C.; Vauzour, David; Vafeiadou, Katerina; Tzounis, Xenofon; Whiteman, Matthew; Rice-Evans, Catherine; Spencer, Jeremy P. E. (2006-12-01)There is much interest in the bioactivity of in vivo flavonoid metabolites. We report for the first time the hierarchy of reactivity of flavonoid metabolites with peroxynitrite and characterise novel reaction products. ...