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Browsing University of Hertfordshire by Author "Siddiqui, Shoib"
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Analysis of SIGLEC12 expression, IMMUNOMODULATION and prognostic value in RENAL cancer using multiomic databases
Ogbodo, Amobichukwu K.; Mustafov, Denis; Arora, Mohit; Lambrou, George I.; Braoudaki, Maria; Siddiqui, Shoib (2024-01-30)Siglecs belong to a family of immune regulatory receptors predominantly found on hematopoietic cells. They interact with Sia, resulting in the activation or inhibition of the immune response. Previous reports have suggested ... -
Chemokines and chemokine receptors in colorectal cancer; multifarious roles and clinical impact
Braoudaki, Maria; Ahmad, Mohammed Saqif; Mustafov, Denis; Seriah, Sara; Siddiqui, Mohammad Naseem; Siddiqui, Shoib (2022-10-13)Colorectal cancer (CRC) is considered the second cause of cancer death worldwide. The early diagnosis plays a key role in patient prognosis and subsequently overall survival. Similar to several types of cancer, colorectal ... -
Differential dose–response effect of cyclosporine A in regulating apoptosis and autophagy markers in MCF-7 cells
Siddiqui, Shoib; Hodeify, Rawad; Mathew, Shimy; Alsawaf, Seba; Alghfeli, Anood; Matar, Rachel; Merheb, Maxime; Marton, John; Al Zouabi, Hussain AbdulKarim; Muthuirulandi Sethuvel, Dhiviya Prabaa; Devanga Ragupathi, Naveen Kumar; Vazhappilly , Cijo George (2023-05-19)Cyclosporine A (CsA) is an immunosuppressant primarily used at a higher dosage in transplant medicine and autoimmune diseases with a higher success rate. At lower doses, CsA exhibits immunomodulatory properties. CsA has ... -
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
Ahmad, Mohammed Saqif; Braoudaki, Maria; Patel, Hershna; Ahmad, Irshad; Waseem, Shagufta; Siddiqui, Shoib (2023-10-06)Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule ... -
Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E
Siddiqui, Shoib; Schwarz, Flavio; Springer, Stevan; Khedri, Zahra; Yu, Hai; Deng, Lingquan; Verhagen, Andrea; Naito-Matsui, Yuko; Jiang, Weiping; Kim, Daniel; Zhou, Jie; Ding, Beibei; Chen, Xi; Varki, Nissi; Varki, Ajit (2017-01-20)CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has ... -
Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E
Siddiqui, Shoib; Schwarz, Flavio; Springer, Stevan; Khedri, Zahra; Yu, Hai; Deng, Lingquan; Verhagen, Andrea; Naito-Matsui, Yuko; Jiang, Weiping; Kim, Daniel; Zhou, Jie; Ding, Beibei; Chen, Xi; Varki, Nissi; Varki, Ajit (2017-01-20)CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has ...