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Browsing University of Hertfordshire by Author "Stapleton, Paul"
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Antibacterial acylphloroglucinols from Hypericum olympicum
Shiu, Winnie K. P.; Rahman, M. Mukhlesur; Curry, Jonathan; Stapleton, Paul; Zloh, Mire; Malkinson, John P.; Gibbons, Simon (2012)New antibacterial acylphloroglucinols (1-5) were isolated and characterized from the aerial parts of the plant Hypericum olympicum L. cf. uniflorum. The structures of these compounds were confirmed by extensive 1D- and ... -
Synthesis and in silico modelling of the potential dual mechanistic activity of small cationic peptides potentiating the antibiotic novobiocin against susceptible and multi-drug resistant Escherichia coli
Passarini, Ilaria; Ernesto de Resende, Pedro; Soares, Sarah; Tahmasi, Tadeh; Stapleton, Paul; Malkinson, John; Zloh, Mire; Rossiter, Sharon (2020-11-30)Cationic antimicrobial peptides have attracted interest, both as antimicrobial agents and for their ability to increase cell permeability to potentiate other antibiotics. However, toxicity to mammalian cells and complexity ...