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Findings from the Tushirikiane mobile health (mHealth) HIV self‐testing pragmatic trial with refugee adolescents and youth living in informal settlements in Kampala, Uganda
(2023-10-18)
Introduction: Urban refugee youth remain underserved by current HIV prevention strategies, including HIV self-testing (HIVST). Examining HIVST feasibility with refugees can inform tailored HIV testing strategies. We examined ...
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
(2023-10-06)
Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule ...
Psychosocial interventions for survivors of rape and sexual assault experienced during adulthood (Review)
(2023-10-05)
Background: Exposure to rape, sexual assault and sexual abuse has lifelong impacts for mental health and well-being. Prolonged Exposure (PE), Cognitive Processing Therapy (CPT) and Eye Movement Desensitisation and Reprocessing ...
Codesigning a systemic discharge intervention for inpatient mental health settings (MINDS): a protocol for integrating realist evaluation and an engineering-based systems approach
(2023-09-13)
Introduction: Transition following discharge from mental health hospital is high risk in terms of relapse, readmission and suicide. Discharge planning supports transition and reduces risk. It is a complex activity involving ...
Digital process control of multi-step assays on centrifugal platforms using high-low-high rotational-pulse triggered valving
(2023-09-08)
Due to their capability for comprehensive sample-to-answer automation, the interest in centrifugal microfluidic systems has greatly increased in industry and academia over the last quarter century. The main applications ...
A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release
(2023-09-04)
Like most non-enveloped viruses, CVB1 mainly uses cell lysis to spread. Details of a nonlytic virus transmission remain unclear. Extracellular Vesicles (EVs) transfer biomolecules between cells. We show that CVB1 entry ...
Profiling alveolar macrophage responses to inhaled compounds using in vitro high content image analysis
(2023-09-01)
One of the main hurdles in the development of new inhaled medicines is the frequent observation of foamy macrophage (FM) responses in non-clinical studies in experimental animals, which raises safety concerns and hinders ...
No prescription? No problem: A qualitative study investigating self-medication with novel psychoactive substances (NPS)
(2023-08-30)
Background The proliferation of Novel Psychoactive Substances (NPS) presents a challenge for global drug policy. The ease of online drug purchase and the emergence of the dark web have created new avenues for the growth ...
Prospective memories in the wild: Predicting memory for intentions in natural environments
(2023-07-31)
Prospective memory, the ability to remember an intention at the appropriate future moment, is often investigated in the laboratory to maximize experimental control. However, demands of laboratory prospective memory tasks ...
Epidemiological Determinants of Patient Non-Conveyance to the Hospital in an Emergency Medical Service Environment
(2023-07-20)
Background: The increasing prevalence of comorbidities worldwide has spurred the need for time-effective pre-hospital emergency medical services (EMS). Some pre-hospital emergency calls requesting EMS result in patient ...