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A Lateral Cap model of microtubule dynamic instability
(1989)
The co-existence and interconversion of growing and shrinking microtubules have been termed ‘dynamic instability’, and have been directly observed to occur under a variety of conditions in vitro and in vivo. Previous ...
A simple formulation of microtubule dynamics: quantitative implications of the dynamic instability of microtubule
(1989)
A simple formulation of microtubule dynamic instability is presented, which is based on the experimental observations by T. Horio and H. Hotani of coexisting, interconverting growing and shrinking microtubules. Employing ...
The effect of podophyllotoxin on microtubule dynamics
(1989)
We have investigated the effects of podophyllotoxin on the dynamic properties of microtubules assembled from pure tubulin dimer. Excess podophyllotoxin causes the complete disassembly of microtubules, through formation of ...
On the relationship between nucleotide hydrolysis and microtubule assembly : Studies with a GTP-regenerating system
(1987)
The assembly of pure tubulin dimer has been studied in two buffer systems (containing low and high glycerol/Mg), using a regeneration system protocol to assess the amount of GDP-tubulin in the assembling polymer. For both ...
Dynamic properties of microtubules at steady state of polymerisation
(1987)
Microtubules of tubulin dimer, polymerised in vitro to steady-state are shown to incorporate tubulin rapidly and extensively. The method involves adding [3H]-GTP to microtubules at steady state, and analysing for ...