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Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis
(2009-05-29)
In the context of trans-dermal drug delivery it is very important to have mechanistic insight into the barrier function of the skin's stratum corneum and the diffusion mechanisms of topically applied drugs. Currently ...
Determination of the diffusion coefficient of cyanophenol in carbosil membrane using ATR-FTIR spectroscopy
(2006-09)
Model membranes are often used in place of human skin when evaluating dermal drug delivery systems. This is because they offer several advantages compared with human epidermis including their ready availability, uniformity ...
Inter- and intralaboratory variation of in vitro diffusion cell measurements : An international multicenter study using quasi-standardized methods and materials
(2005-03)
In vitro measurements of skin absorption are an increasingly important aspect of regulatory studies, product support claims, and formulation screening. However, such measurements are significantly affected by skin variability. ...