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Investigation of the mode of action of nematode neuropeptides
(1996-03)
The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, ...
Metabolism of AF1 (KNEFIRF-NH2) in the nematode, Ascaris suum, by aminopeptidases, endopeptidase and deaminase enzymes
(1996-01)
We have studied the metabolism and inactivation of AF1 (KNEFIRF-NH2) by membranes prepared from the locomotory muscle of Ascaris suum. FIRF-NH2, NEFIRF-NH2 and KNEFIRF were identified as three primary degradation products, ...