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Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates
(2004-02-23)
Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by ...
Molecular similarity of MDR inhibitors
(2004-02-01)
The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of ...