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Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
(2020-10-01)
S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ...
Identifying Lead Compounds for S100P in Pancreatic Cancer Therapy Using in Vitro Biophysical Techniques
(2016-06-27)
The protein S100P has been associated with the aggressiveness of several neoplastic disease, including pancreatic ductal adenocarcinoma (PDAC). S100 proteins are a family of calcium binding proteins that are small dimeric ...
Design, Synthesis and Biological Evaluation of Potential Inhibitors of S100P, a Protein implicated in Pancreatic Cancer
(2016-04-18)
Pancreatic cancer is relatively uncommon. Despite its relative scarcity, it is the fourth-ranked cancer killer in the Western world with less than a 5% 5-year survival rate. The high mortality rate is due to the asymptomatic ...