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Genetic algorithms and their application to in silico evolution of genetic regulatory networks
(2010)
A genetic algorithm (GA) is a procedure that mimics processes occurring in Darwinian evolution to solve computational problems. A GA introduces variation through "mutation" and "recombination" in a "population" of possible ...
Do Motifs Reflect Evolved Function? – No Convergent Evolution of Genetic Regulatory Network Subgraph Topologies
(2008-10)
Methods that analyse the topological structure of networks have recently become quite popular. Whether motifs (subgraph patterns that occur more often than in randomized networks) have specific functions as elementary ...
Evolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional information
(MIT Press, 2008)
Development is the powerful process involving a genome in the transformation from one egg cell to a multicellular organism with many cell types. The dividing cells manage to organize and assign themselves special, ...
Regulation of gene regulation - smooth binding with dynamic affinity affects evolvability
(Institute of Electrical and Electronics Engineers (IEEE), 2008)
The Essential Motif that wasn't there: Topological and Lesioning Analysis of Evolved Genetic Regulatory Networks
(Institute of Electrical and Electronics Engineers (IEEE), 2007)
Evolutionary robustness of differentiation in genetic regulatory networks
(IOS Press, 2006)
We investigate the ability of artificial Genetic Regulatory Networks (GRNs) to evolve differentiation. The proposed GRN model supports non-linear interaction between regulating factors, thereby facilitating the realization ...
Evolving biological clocks using genetic regulatory networks
(MIT Press, 2006)