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The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
(2009-04-01)
Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) ...
Glial metabolism of quercetin reduces its neurotoxic potential
(2008-10-15)
The neuroprotective effects of flavonoids will ultimately depend on their interaction with both neuronal and glial cells. In this study, we show that the potential neurotoxic effects of quercetin are modified by glial cell ...
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenols
(2008-08-15)
Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-c ...