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Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation

Lione, Lisa; Carter, R. J.; Hunt, M. J.; Bates, G. P.; Morton, A. J.; Dunnett, S B (1999-12-01)

Cognitive decline is apparent in the early stages of Huntington's disease and progressively worsens throughout the course of the disease. Expression of the human Huntington's disease mutation in mice (R6/2 line) causes a ...

Effects of severity and timing of stem canker (Leptosphaeria maculans) symptoms on yield of winter oilseed rape (Brassica napus) in the UK

Zhou, Y.; Fitt, Bruce D.L.; Welham, S.J.; Gladders, P.; Sansford, C.E.; West, Jon S. (1999-10)

The relationships between yield loss and incidence (% plants with stems affected) or severity (mean stem score, 0-4 scale) of stem canker in winter oilseed rape were analysed using data from experiments at Rothamsted in ...

Epidemiology of Leptosphaeria maculans in relation to forecasting stem canker severity on winter oilseed rape in the UK

West, Jon S.; Biddulph, J.E.; Fitt, Bruce D.L.; Gladders, P. (1999-10)

In the UK, ascospores of Leptosphaeria maculans first infect leaves of oilseed rape in the autumn to cause phoma leaf spots, from which the fungus can grow to cause stem cankers in the spring. Yield losses due to early ...

Plant-insect interactions

Stotz, Henrik; Kroymann, J.; Mitchell-Olds, T. (1999-08)

Recent research shows partially overlapping signal transduction pathways controlling responses to wounding, insects, and pathogens. Chemical and behavioral assays show that plants release herbivore-specific volatiles, and ...

Novel selective compounds for the investigation of imidazoline receptors

Hudson, A.L.; Gough, R.; Tyacke, Robin; Lione, Lisa; Lalies, M.D.; Lewis, J.; Husbands, S.; Knight, P.; Murray, F.; Hutson, P.; Nutt, D.J. (1999-06)

Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved ...

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation

Lione, Lisa; Carter, R. J.; Humby, T.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J. (1999-04-15)

Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 141-157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have ...

Exposing the human nude phenotype [4]

Frank, J.; Pignata, C.; Panteleyev, A. A.; Prowse, David M.; Baden, H.; Weiner, L.; Gaetaniello, L.; Ahmad, W.; Pozzi, N.; Cserhalmi-Friedman, P. B.; Aita, V. M.; Uyttendaele, H.; Gordon, D.; Ott, J.; Brissette, J. L.; Christiano, A. M. (1999-04-08)

Is there a rationale for rationing chronic dialysis? : A hospital based cohort study of factors affecting survival and morbidity

Chandna, S.M.; Schulz, J.; Lawrence, C.; Greenwood, R.N.; Farrington, Ken (1999-01-23)

Objectives To determine factors influencing survival and need for hospitalisation in patients needing dialysis, and to define the potential basis for rationing access to renal replacement therapy. Design Hospital based ...

Infectivity of ascospores of Pyrenopeziza brassicae on leaves and factors affecting maturation of apothecia on debris of oilseed rape

Gilles, T.; Fitt, Bruce D.L. (Association of Applied Biologists, 1999)

Biodiversity-threatened by GMOs?

Barling, David (1999)

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