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The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
(2011-11)
Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ...
STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron
(2011)
Neurons in the cerebellar nuclei (CN) receive inhibitory inputs from Purkinje cells in the cerebellar cortex and provide the major output from the cerebellum, but their computational function is not well understood. It has ...
Effect of using varying negative examples in transcription factor binding site predictions
(2011)
Identifying transcription factor binding sites computationally is a hard problem as it produces many false predictions. Combining the predictions from existing predictors can improve the overall predictions by using ...