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The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs
(1993-09)
Plasma concentrations of febantel and its major metabolites fenbendazole, oxfendazole and oxfendazole sulphone were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection ...
Pharmacokinetics and clinical effects in dogs of a sustained-release formulation of theophylline
(1993-08)
Theophylline was administered orally in a sustained-release preparation at a dose rate of 20 mg/kg bodyweight to six beagle dogs. A mean (+/- se) maximum plasma concentration of 12.2 +/- 0.65 micrograms/ml was obtained ...
Interactions of Ostertagia species with their bovine and ovine hosts
(1993-07)
Ostertagia spp. affect their hosts in several complex interactions involving structural, biochemical, hormonal, nutritional and immunological mechanisms. Following infection with Ostertagia spp. the specialised secretory ...
Oral absorption and bioavailability of fenbendazole in the dog and the effect of concurrent ingestion of food
(1993-06)
Fenbendazole was administered orally without food to six beagle dogs at 2.5, 5.0, 10, 20, 40 and 80 mg/kg of body weight. Increasing the dose rate did not significantly increase the amount of fenbendazole absorbed. In a ...
The pharmacokinetics of flunixin meglumine in the sheep
(1993-06)
Flunixin meglumine was administered intravenously and intramuscularly in sheep and the pharmacokinetics of the drug studied. Plasma concentrations of flunixin were measured by high performance liquid chromatography. The ...
Factors affecting the clinical outcome of injuries to the superficial digital flexor tendon in National Hunt and point-to-point racehorses.
(1993-05-08)
Ultrasonographic examination was used to define the severity of injuries to the superficial digital flexor tendon in 73 National Hunt or point-to-point racehorses and the factors influencing the outcome of the cases were ...
Pharmacokinetics and applications of ampicillin sodium as an intravenous infusion in the horse
(1993-03)
A regime for administration of ampicillin sodium by continuous intravenous infusions to horses was designed. The aim was to achieve plasma ampicillin concentrations between 5 and 10 micrograms/ml over a 4-h period. A 2 ...
A high performance liquid chromatographic method for the determination of febantel and its major metabolites in lamb plasma
(1993-03)
A high performance liquid chromatographic (HPLC) method for the determination of the anthelminthic pro-benzimidazole febantel and its major metaboites in lamb plasma has been developed. Samples were extracted after addition ...
Pharmacodynamics, pharmacokinetics and faecal persistence of morantel in cattle and goats
(1993-03)
Morantel could not be detected (<0.05 microgram/ml) in the plasma of cattle or goats following the oral administration of morantel tartrate at a dose rate of 10 mg/kg bodyweight. No morantel was detected in the milk of ...