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Appraisal fails expectations
(Haymarket Media Group, 2005-12-02)
Studies On Formulation And Evaluation Of Ranitidine Floating Tablets
Present investigation highlights the formulation and optimization of floating tablets of ranitidine hydrochloride. Formulations were optimized for type of filler, different viscosity grades of hydroxypropylmethylcellulose ...
Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women : interactions with genotype and equol production
Dietary isoflavones are thought to be cardioprotective because of their structural similarity to estrogen. The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by ...
Agrobacterium tumefaciens-mediated transformation of Leptosphaeria spp. and Oculimacula spp. with the reef coral gene DsRed and the jellyfish gene gfp
Four filamentous ascomycetes, Leptosphaeria maculans, L. biglobosa, Oculimacula yallundae and O. acuformis, were transformed via Agrobacterium tumefaciens-mediated transformation with the genes encoding DsRed and GFP. Using ...
Effects of Apamin and Charybdtoxin on Endothelium Independent Vasodilatation : Implications in the study of EDHF
Endothelial derived hyperpolarizing factor (EDHF), together with endothelial derived NO and prostacyclin represent the major endogenous vasodilator hormone pathways (Coleman et al, 2004). Since the chemical nature of EDHF ...
The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers
The objective of the present study was to investigate the physical stability of spray-dried proteins within surfactant-free hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs) during prolonged storage. Two ...
The lost science of formulation
The current R&D outsourcing market is growing annually at ∼15%, with a predicted market of US$36 billion by 2010. However, top tier contract research organizations (CROs) are attempting to transform their profitability by ...
The cellular response to transglutaminase-cross-linked collagen
Collagen, type 1, is a highly abundant natural protein material which has been cross-linked by 11 variety of methods including chemical agents, physical heating and UV irradiation with the aim of enhancing its physical ...
Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation ...