Search
Now showing items 1-8 of 8
Pharmacokinetics of bacampicillin in equids
(1995)
Bacampicillin hydrochloride is an ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract. It was administered intragastrically at a dose rate of 13.5 mg/kg of body weight to ...
Ampicillin and its congener prodrugs in the horse
(1994-03)
Ampicillin is an antibiotic commonly administered to horses by both the intramuscular (i.m.) and the intravenous (i.v.) route. Its physicochemical properties restrict its absorption after oral administration and explain ...
Pharmacokinetics and applications of ampicillin sodium as an intravenous infusion in the horse
(1993-03)
A regime for administration of ampicillin sodium by continuous intravenous infusions to horses was designed. The aim was to achieve plasma ampicillin concentrations between 5 and 10 micrograms/ml over a 4-h period. A 2 ...
Effect of probenecid on disposition kinetics of ampicillin in horses
(1992-08)
The effect of an oral dose of probenecid on the disposition kinetics of ampicillin was determined in four horses. An intravenous bolus dose (10 mg/kg) of ampicillin sodium was administered to the horses on two occasions. ...
Effect of changes in urine pH on plasma pharmacokinetic variables of ampicillin sodium in horses
(1992)
The effect of urine pH on plasma disposition of ampicillin sodium was evaluated. A single dose of 10 mg/kg of body weight was administered IV to Thoroughbreds with alkaline (pH greater than 8.0) or acidic (pH less than ...